DegronMD

Uniprot ID: O15034

Source protein: RIMS-binding protein 2

Source gene: RIMBP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 688:694

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.92

ASA_SCORE: 99.8286

COIL: 0.5021

CONS_SCORE: 0.4128

DSS_SCORE: 0.4115

HELIX: 0.374

FCONS_SCORE: 1.0067

RIG_SCORE: 0.7677

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A698V	TCGA-59-2349	OV	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A698V	TCGA-AA-3966	COAD	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A698V	DO10068	COAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A698V	DO230524	LUSC	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A698V	DO28621	OV	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A698V	SIDM00217	Colorectal Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A698V	ACH-000999	Colon/Colorectal Cancer	CCLE	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A698V	SNU-1040	large_intestine	COSMIC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A703S	TCGA-85-7843	LUSC	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A703S	DO26500	LUSC	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A698T	TCGA-BR-8371	STAD	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A698T	TCGA-DB-A64S	LGG	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A698T	DO44619	LGG	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A698T	DO47950	STAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S690G	TCGA-BS-A0TJ	UCEC	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.6993
p.S690G	DO42953	UCEC	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.6993
p.E694D	TCGA-DA-A3F5	SKCM	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E694D	DO37435	SKCM	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.5647
p.G699R	TCGA-DI-A1BU	UCEC	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G699R	DO42023	UCEC	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E687D	TCGA-G4-6323	COAD	TCGA	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E687D	DO9138	COAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R689K	DO48389	BLCA	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.6126
p.A702T	DO234219	ESAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q700R	DO233734	GACA	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S683C	DO51962	PRAD	ICGC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q678H	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V691L	SIDM00231	Kidney Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.5654
p.V691L	NCC010	kidney	COSMIC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.5654
p.V691I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V691I	SIDM01147	Gastric Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.G699W	SIDM01387	Small Cell Lung Carcinoma	GDSC	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G699W	ACH-000921	Lung Cancer	CCLE	KRSVFLE	LIG_APCC_ABBAyCdc20_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRSVFLE

Degron related mutations and impact score

Drug responses associated with RIMBP2 mutations

All proteins holding degron of KRSVFLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15034	RIMS-binding protein 2	LIG_APCC_ABBAyCdc20_2	688:694	KRSVFLE	APC,CDC20,FZR1	0.92	More...