DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 2521:2525

E3 ligase: SPOP

DEGRON score: 0.799

ASA_SCORE: 86.06

COIL: 0.8248

CONS_SCORE: 0.5236

DSS_SCORE: 0.4804

HELIX: 0.008

FCONS_SCORE: 1

RIG_SCORE: 0.7281

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2535F	TCGA-A6-6781	COAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0556
p.L2535F	DO8447	COAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0556
p.E2531D	TCGA-DU-6392	LGG	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E2531D	DO22237	LGG	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E2512K	TCGA-E7-A541	BLCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2512K	DO44037	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.0833
p.E2531Q	TCGA-FD-A3B3	BLCA	TCGA	PVSTT	DEG_SPOP_SBC_1	0.1667
p.E2531Q	DO749	BLCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.1667
p.T2525M	TCGA-MA-AA3Y	CESC	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T2525M	TCGA-MP-A4T7	LUAD	TCGA	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T2525M	DO219721	CESC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T2525M	DO234413	ESAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T2525M	DO48221	ESCA	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.T2525M	DO45370	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	0.7423
p.I2520M	DO227427	EOPC	ICGC	PVSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	458:462	PVSTT	SPOP	0.8219	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.615	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1284:1288	PVSTT	SPOP	0.7705	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1402:1406	PVSTT	SPOP	0.678	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1755:1759	PVSTT	SPOP	0.7406	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1932:1936	PVSTT	SPOP	0.9647	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2050:2054	PVSTT	SPOP	0.8263	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2167:2171	PVSTT	SPOP	0.6746	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2344:2348	PVSTT	SPOP	0.9456	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2462:2466	PVSTT	SPOP	0.5519	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2521:2525	PVSTT	SPOP	0.799	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3052:3056	PVSTT	SPOP	0.791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3111:3115	PVSTT	SPOP	0.5181	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3287:3291	PVSTT	SPOP	0.9282	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3523:3527	PVSTT	SPOP	0.8654	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3641:3645	PVSTT	SPOP	0.6776	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3700:3704	PVSTT	SPOP	0.7947	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1166:1170	PVSTT	SPOP	0.9956	More...
Q6ZSZ6	Teashirt homolog 1	DEG_SPOP_SBC_1	164:168	PVSTT	SPOP	0.8971	More...
Q8IWK6	Adhesion G protein-coupled receptor A3	DEG_SPOP_SBC_1	1256:1260	PVSTT	SPOP	0.997	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7701:7705	PVSTT	SPOP	0.9414	More...
Q96RL7	Intermembrane lipid transfer protein VPS13A	DEG_SPOP_SBC_1	1023:1027	PVSTT	SPOP	0.8888	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	1290:1294	PVSTT	SPOP	0.9197	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1737:1741	PVSTT	SPOP	0.9631	More...
O15034	RIMS-binding protein 2	DEG_SPOP_SBC_1	663:667	PVSTT	SPOP	0.6642	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	637:641	PVSTT	SPOP	0.942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVSTT