DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DLTMVLYSPGP
Uniprot ID:
Q96RL7
Source protein:
Intermembrane lipid transfer protein VPS13A
Source gene:
VPS13A
Class:
CBL_PTK
Location:
1402:1412
E3 ligase:
CBL
DEGRON score:
0.5728
ASA_SCORE:
32.9636
COIL:
0.3827
CONS_SCORE:
0.3399
DSS_SCORE:
0.2218
HELIX:
0.0157
FCONS_SCORE:
1.2222
RIG_SCORE:
0.8063
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1409G
TCGA-B5-A1MW
UCEC
TCGA
DLTMVLYSPGP
CBL_PTK
0.8104
p.S1409G
DO42913
UCEC
ICGC
DLTMVLYSPGP
CBL_PTK
0.8104
p.M1405I
TCGA-BF-A1PZ
SKCM
TCGA
DLTMVLYSPGP
CBL_PTK
0.6507
p.M1405I
DO50279
SKCM
ICGC
DLTMVLYSPGP
CBL_PTK
0.6507
p.S1416F
TCGA-DA-A95Z
SKCM
TCGA
DLTMVLYSPGP
CBL_PTK
0.6667
p.S1416F
DO219481
SKCM
ICGC
DLTMVLYSPGP
CBL_PTK
0.6667
p.S1409N
TCGA-EK-A2R8
CESC
TCGA
DLTMVLYSPGP
CBL_PTK
0.818
p.S1409N
DO51599
CESC
ICGC
DLTMVLYSPGP
CBL_PTK
0.818
p.P1410Q
TCGA-ER-A19P
SKCM
TCGA
DLTMVLYSPGP
CBL_PTK
0.5924
p.P1410Q
DO47623
SKCM
ICGC
DLTMVLYSPGP
CBL_PTK
0.5924
p.Y1408C
DO218269
BRCA
ICGC
DLTMVLYSPGP
CBL_PTK
0.7087
p.G1411V
DO48225
ESCA
ICGC
DLTMVLYSPGP
CBL_PTK
0.6421
p.Y1408H
DO233867
GACA
ICGC
DLTMVLYSPGP
CBL_PTK
0.7229
p.Y1408H
DO221541
PACA
ICGC
DLTMVLYSPGP
CBL_PTK
0.7229
p.S1409I
DO228974
LICA
ICGC
DLTMVLYSPGP
CBL_PTK
0.8453
p.S1409I
SIDM00660
Colorectal Carcinoma
GDSC
DLTMVLYSPGP
CBL_PTK
0.8453
p.S1409I
ACH-000985
Colon/Colorectal Cancer
CCLE
DLTMVLYSPGP
CBL_PTK
0.8453
p.S1409I
LS-411N
large_intestine
COSMIC
DLTMVLYSPGP
CBL_PTK
0.8453
p.R1421L
DO229031
LICA
ICGC
DLTMVLYSPGP
CBL_PTK
0.0833
p.S1409T
DO230541
LUSC
ICGC
DLTMVLYSPGP
CBL_PTK
0.7116
p.R1421C
DO27809
MALY
ICGC
DLTMVLYSPGP
CBL_PTK
0.0833
p.G1406S
DMS-273
lung
COSMIC
DLTMVLYSPGP
CBL_PTK
0.6993
Drug responses associated with VPS13A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLTMVLYSPGP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96RL7
Intermembrane lipid transfer protein VPS13A
CBL_PTK
1402:1412
DLTMVLYSPGP
CBL
0.5728
More...