DegronMD

Uniprot ID: Q96RL7

Source protein: Intermembrane lipid transfer protein VPS13A

Source gene: VPS13A

Class: LIG_APCC_ABBAyCdc20_2

Location: 2497:2503

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5944

ASA_SCORE: 26.3429

COIL: 0.1943

CONS_SCORE: 0.3914

DSS_SCORE: 0.0366

HELIX: 0.0069

FCONS_SCORE: 1.3063

RIG_SCORE: 0.9343

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y2487C	TCGA-66-2744	LUSC	TCGA	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Y2487C	DO27025	LUSC	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R2497C	TCGA-BF-AAP1	SKCM	TCGA	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R2497C	DO230342	COCA	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R2497C	DO219464	SKCM	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R2497C	SIDM00983	Bladder Carcinoma	GDSC	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R2497C	ACH-000896	Bladder Cancer	CCLE	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R2497C	647-V	urinary_tract	COSMIC	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R2497H	DO222864	COCA	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R2497H	DO222354	LICA	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R2497L	DO229015	LICA	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.8428
p.R2506S	DO35083	PACA	ICGC	RIILFTE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RL7	Intermembrane lipid transfer protein VPS13A	LIG_APCC_ABBAyCdc20_2	2497:2503	RIILFTE	APC,CDC20,FZR1	0.5944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons