DegronMD

Uniprot ID: Q9P206

Source protein: Uncharacterized protein KIAA1522

Source gene: KIAA1522

Class: DEG_SCF_FBW7_2

Location: 655:660

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 109.8167

COIL: 0.9593

CONS_SCORE: 0.5507

DSS_SCORE: 0.8549

HELIX: 0.0193

FCONS_SCORE: 1.0732

RIG_SCORE: 0.6396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G647W	TCGA-D3-A2JC	SKCM	TCGA	LTPLQE	DEG_SCF_FBW7_2	0.1111
p.R645C	TCGA-DU-7010	LGG	TCGA	LTPLQE	DEG_SCF_FBW7_2	0.0556
p.H663Y	TCGA-SY-A9G5	BLCA	TCGA	LTPLQE	DEG_SCF_FBW7_2	0.25
p.Q646K	DO51903	BLCA	ICGC	LTPLQE	DEG_SCF_FBW7_2	0.0833
p.S661F	DO219589	BRCA	ICGC	LTPLQE	DEG_SCF_FBW7_2	0.3056
p.P657Q	DO227987	COCA	ICGC	LTPLQE	DEG_SCF_FBW7_2	0.7035
p.E660V	DO41235	UCEC	ICGC	LTPLQE	DEG_SCF_FBW7_2	0.7693
p.R645H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LTPLQE	DEG_SCF_FBW7_2	0.0556
p.R645H	SIDM00282	Colorectal Carcinoma	GDSC	LTPLQE	DEG_SCF_FBW7_2	0.0556
p.R645H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLQE	DEG_SCF_FBW7_2	0.0556
p.R645H	CW-2	large_intestine	COSMIC	LTPLQE	DEG_SCF_FBW7_2	0.0556
p.S647F	ACH-000607	Rhabdoid	CCLE	LTPLQE	DEG_SCF_FBW7_2	0.1111
p.S647F	KYM-1	soft_tissue	COSMIC	LTPLQE	DEG_SCF_FBW7_2	0.1111
p.Q668L	ACH-002123	Lung Cancer	CCLE	LTPLQE	DEG_SCF_FBW7_2	0.1111
p.Q668L	H2369	pleura	COSMIC	LTPLQE	DEG_SCF_FBW7_2	0.1111
p.S658F	KYM-1	soft_tissue	COSMIC	LTPLQE	DEG_SCF_FBW7_2	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P206	Uncharacterized protein KIAA1522	DEG_SCF_FBW7_2	655:660	LTPLQE	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons