DegronMD

Uniprot ID: Q9P206

Source protein: Uncharacterized protein KIAA1522

Source gene: KIAA1522

Class: DEG_SCF_FBW7_1

Location: 648:654

E3 ligase: FBXW7

DEGRON score: 0.9907

ASA_SCORE: 98.7714

COIL: 0.9559

CONS_SCORE: 0.5423

DSS_SCORE: 0.8524

HELIX: 0.0173

FCONS_SCORE: 1.0856

RIG_SCORE: 0.5805

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G647W	TCGA-D3-A2JC	SKCM	TCGA	PPTPQTT	DEG_SCF_FBW7_1	0.3056
p.R645C	TCGA-DU-7010	LGG	TCGA	PPTPQTT	DEG_SCF_FBW7_1	0.25
p.H663Y	TCGA-SY-A9G5	BLCA	TCGA	PPTPQTT	DEG_SCF_FBW7_1	0.0833
p.Q646K	DO51903	BLCA	ICGC	PPTPQTT	DEG_SCF_FBW7_1	0.2778
p.S661F	DO219589	BRCA	ICGC	PPTPQTT	DEG_SCF_FBW7_1	0.1389
p.A643T	DO13863	GBM	ICGC	PPTPQTT	DEG_SCF_FBW7_1	0.1944
p.P649S	DO26444	LUSC	ICGC	PPTPQTT	DEG_SCF_FBW7_1	0.5641
p.R645H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPTPQTT	DEG_SCF_FBW7_1	0.25
p.R645H	SIDM00282	Colorectal Carcinoma	GDSC	PPTPQTT	DEG_SCF_FBW7_1	0.25
p.R645H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPQTT	DEG_SCF_FBW7_1	0.25
p.R645H	CW-2	large_intestine	COSMIC	PPTPQTT	DEG_SCF_FBW7_1	0.25
p.D644N	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPQTT	DEG_SCF_FBW7_1	0.2222
p.D644N	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPQTT	DEG_SCF_FBW7_1	0.2222
p.S647F	ACH-000607	Rhabdoid	CCLE	PPTPQTT	DEG_SCF_FBW7_1	0.3056
p.S647F	KYM-1	soft_tissue	COSMIC	PPTPQTT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P206	Uncharacterized protein KIAA1522	DEG_SCF_FBW7_1	648:654	PPTPQTT	FBXW7	0.9907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons