DegronMD

Uniprot ID: O95271

Source protein: Poly [ADP-ribose] polymerase tankyrase-1

Source gene: TNKS

Class: DEG_ODPH_VHL_1

Location: 53:65

E3 ligase: VHL

DEGRON score: 0.9838

ASA_SCORE: 55.9308

COIL: 0.7166

CONS_SCORE: 0.2859

DSS_SCORE: 0.7137

HELIX: 0.0762

FCONS_SCORE: 0.9738

RIG_SCORE: 0.6097

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T43A	TCGA-B2-3923	KIRC	TCGA	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.0556
p.T43A	DO18889	KIRC	ICGC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.0556
p.L53M	TCGA-HU-8602	STAD	TCGA	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.711
p.L53M	DO47829	STAD	ICGC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.711
p.G70V	DO228925	LICA	ICGC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.1944
p.G70V	ACH-000458	Skin Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.1944
p.R60L	SIDM00648	Small Cell Lung Carcinoma	GDSC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.7316
p.R60L	ACH-002169	Lung Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.7316
p.R60L	NCI-H1304	lung	COSMIC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.7316
p.G68V	SIDM00120	Prostate Carcinoma	GDSC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.25
p.G68V	ACH-000979	Prostate Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.25
p.G68V	DU-145	prostate	COSMIC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.25
p.D59E	ACH-000070	Leukemia	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.6758
p.D59E	697	haematopoietic_and_lymphoid_tissue	COSMIC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.6758
p.I62V	ACH-000612	Lymphoma	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.7076
p.I73V	ACH-000867	Lung Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.1111
p.I73V	ChaGo-K-1	lung	COSMIC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.1111
p.L64P	ACH-000985	Colon/Colorectal Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.7582
p.L64P	LS-411N	large_intestine	COSMIC	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.7582
p.P48L	ACH-001524	Skin Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.1944
p.S47F	ACH-001853	Bile Duct Cancer	CCLE	LAPFASPRHGLAL	DEG_ODPH_VHL_1	0.1667

Drug responses associated with TNKS mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Q1325H (No)	GDSC	XAV939	85.987
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	XAV939	70.6467
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	XAV939	291.17
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	MN-64	230.21
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	WIKI4	40.489
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	AZ6102	88.198
SIDM00839	COREAD\|large_intestine	p.S134delS (No)	GDSC	XAV939	31.9722
SIDM00839	COREAD\|large_intestine	p.S134delS (No)	GDSC	XAV939	198.58
SIDM00839	COREAD\|large_intestine	p.S134delS (No)	GDSC	MN-64	248.22
SIDM00839	COREAD\|large_intestine	p.S134delS (No)	GDSC	WIKI4	148.93
SIDM00839	COREAD\|large_intestine	p.S134delS (No)	GDSC	AZ6102	7.1508
SIDM00578	NB\|neuroblastoma	p.A599T (No)	GDSC	XAV939	62.2554
SIDM00578	NB\|neuroblastoma	p.A599T (No)	GDSC	WIKI4	12.557
SIDM00578	NB\|neuroblastoma	p.A599T (No)	GDSC	AZ6102	63.59
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R383K (No)	GDSC	XAV939	79.3525
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R383K (No)	GDSC	WIKI4	24.51
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R383K (No)	GDSC	AZ6102	34.542
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.H705R (No)	GDSC	XAV939	26.3351
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	XAV939	23.2978
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	XAV939	15.182
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	MN-64	29.879
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	WIKI4	9.4223
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	AZ6102	1.6334
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	XAV939	16.9117
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	XAV939	100.54
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	MN-64	64.865
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	WIKI4	34.912
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	AZ6102	7.9351
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	XAV939	54.1713
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	XAV939	660.46
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	MN-64	266.56
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	WIKI4	77.804
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	AZ6102	105.5
SIDM00550	ESCA\|oesophagus	p.G122S (No)	GDSC	XAV939	50.7815
SIDM00550	ESCA\|oesophagus	p.G122S (No)	GDSC	XAV939	77.275
SIDM00550	ESCA\|oesophagus	p.G122S (No)	GDSC	MN-64	140.69
SIDM00550	ESCA\|oesophagus	p.G122S (No)	GDSC	WIKI4	35.27
SIDM00550	ESCA\|oesophagus	p.G122S (No)	GDSC	AZ6102	9.8282
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.L807F (No)	GDSC	XAV939	31.6494
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.L807F (No)	GDSC	XAV939	92.715
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.L807F (No)	GDSC	MN-64	91.757
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	XAV939	28.1116
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	XAV939	247.6
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	MN-64	118.17
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	WIKI4	39.52
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	AZ6102	16.971
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	XAV939	45.6414
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	XAV939	31.094
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	MN-64	103.44
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	WIKI4	26.656
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	AZ6102	10.89
SIDM00466	OV\|ovary	p.G1026V (No)	GDSC	XAV939	251.4354
SIDM00466	OV\|ovary	p.G1026V (No)	GDSC	WIKI4	96.525
SIDM00466	OV\|ovary	p.G1026V (No)	GDSC	AZ6102	544.64
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	XAV939	13.7175
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	XAV939	32.643
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	MN-64	31.387
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	WIKI4	37.338
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	AZ6102	3.084
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	XAV939	43.9755
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	XAV939	84.099
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	MN-64	267.11
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	WIKI4	38.357
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	AZ6102	7.2998
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	XAV939	18.2292
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	XAV939	110.15
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	MN-64	201.25
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	WIKI4	25.204
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	AZ6102	9.7102
SIDM01133	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A117P (No)	GDSC	XAV939	22.0108
SIDM01133	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A117P (No)	GDSC	WIKI4	136.35
SIDM01133	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A117P (No)	GDSC	AZ6102	5.2125
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.S726L (No)	GDSC	XAV939	59.5866
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	XAV939	109.662
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	XAV939	119.18
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	MN-64	235.8
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	WIKI4	26.924
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	AZ6102	11.064
SIDM00303	OV\|ovary	p.S91I (No)	GDSC	XAV939	7.3161
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	XAV939	17.7995
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	XAV939	55.072
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	MN-64	97.883
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	WIKI4	32.948
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	AZ6102	5.8907
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	XAV939	33.12
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	XAV939	47.82
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	MN-64	139.06
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	WIKI4	23.719
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	AZ6102	13.248
SIDM00217	COREAD\|large_intestine	p.A1269V (No)	GDSC	XAV939	56.0028
SIDM00217	COREAD\|large_intestine	p.A1269V (No)	GDSC	XAV939	87.794
SIDM00217	COREAD\|large_intestine	p.A1269V (No)	GDSC	MN-64	234.76
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (No)	GDSC	XAV939	9.9121
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (No)	GDSC	XAV939	40.346
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (No)	GDSC	MN-64	41.058
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (No)	GDSC	WIKI4	44.377
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (No)	GDSC	AZ6102	10.693
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	XAV939	30.058
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	XAV939	14.922
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	MN-64	41.348
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	WIKI4	64.865
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	AZ6102	6.1498
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	XAV939	127.0465
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	XAV939	72.076
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	MN-64	234.68
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	WIKI4	65.973
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	AZ6102	81.504
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	XAV939	32.0149
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	XAV939	197.08
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	MN-64	245.83
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	WIKI4	27.828
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	AZ6102	10.241
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	XAV939	33.488
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	XAV939	21.277
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	MN-64	39.347
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	WIKI4	40.521
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	AZ6102	24.862
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	XAV939	40.0201
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	XAV939	167.43
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	MN-64	140.28
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	WIKI4	89.924
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	AZ6102	9.804
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	XAV939	40.0201
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	XAV939	167.43
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	MN-64	140.28
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	WIKI4	89.924
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	AZ6102	9.804
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	XAV939	40.0201
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	XAV939	167.43
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	MN-64	140.28
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	WIKI4	89.924
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	AZ6102	9.804
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.H859R (No)	GDSC	XAV939	20.6881
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.H859R (No)	GDSC	WIKI4	43.494
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.H859R (No)	GDSC	AZ6102	12.367
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	XAV939	38.9965
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	XAV939	93.678
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	MN-64	81.255
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	WIKI4	44.17
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	AZ6102	9.9173
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	XAV939	18.5747
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	XAV939	48.075
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	MN-64	81.085
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	WIKI4	36.023
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	AZ6102	6.1789
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	XAV939	100.4499
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	XAV939	71.743
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	MN-64	270.02
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	WIKI4	41.636
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	AZ6102	5.0573
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.I310V (No)	GDSC	XAV939	27.5392
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.H1100L (No)	GDSC	XAV939	59.9957
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.M584L (No)	GDSC	XAV939	60.9642
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.M584L (No)	GDSC	XAV939	63.82
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.M584L (No)	GDSC	MN-64	79.419
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	XAV939	61.4203
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	XAV939	30.454
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	MN-64	168.26
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	WIKI4	49.78
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	AZ6102	10.625
SIDM00534	COREAD\|large_intestine	p.R383* (No)	GDSC	XAV939	61.5614
SIDM00534	COREAD\|large_intestine	p.R383* (No)	GDSC	XAV939	188.95
SIDM00534	COREAD\|large_intestine	p.R383* (No)	GDSC	MN-64	172.11
SIDM00534	COREAD\|large_intestine	p.R383Q (No)	GDSC	XAV939	61.5614
SIDM00534	COREAD\|large_intestine	p.R383Q (No)	GDSC	XAV939	188.95
SIDM00534	COREAD\|large_intestine	p.R383Q (No)	GDSC	MN-64	172.11
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	XAV939	102.427
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	XAV939	169.39
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	MN-64	69.824
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	WIKI4	26.953
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	AZ6102	33.407
SIDM00217	COREAD\|large_intestine	p.T508fs*33 (No)	GDSC	XAV939	56.0028
SIDM00217	COREAD\|large_intestine	p.T508fs*33 (No)	GDSC	XAV939	87.794
SIDM00217	COREAD\|large_intestine	p.T508fs*33 (No)	GDSC	MN-64	234.76
SIDM00191	KIRC\|kidney	p.A920T (No)	GDSC	XAV939	19.8717
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	XAV939	34.6906
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	XAV939	55.059
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	MN-64	139.07
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	WIKI4	146.88
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	AZ6102	59.89
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	XAV939	19.908
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	XAV939	42.133
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	MN-64	86.954
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	WIKI4	21.708
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	AZ6102	6.0872
SIDM00120	PRAD\|prostate	p.G68V (Yes)	GDSC	XAV939	2.9243
SIDM00120	PRAD\|prostate	p.G68V (Yes)	GDSC	XAV939	273.2
SIDM00120	PRAD\|prostate	p.G68V (Yes)	GDSC	MN-64	309.57
SIDM00120	PRAD\|prostate	p.G68V (Yes)	GDSC	WIKI4	104.93
SIDM00120	PRAD\|prostate	p.G68V (Yes)	GDSC	AZ6102	83.293
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	XAV939	10.7811
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	XAV939	75.35
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	MN-64	32.346
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	WIKI4	34.56
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	AZ6102	21.284
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	XAV939	9.766
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	XAV939	29.351
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	MN-64	58.577
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	WIKI4	4.6635
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	AZ6102	4.3586
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	XAV939	24.5716
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	XAV939	90.205
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	MN-64	191.54
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	WIKI4	72.138
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	AZ6102	11.373
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	XAV939	26.8047
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	XAV939	65.54
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	MN-64	166.58
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	WIKI4	46.604
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	AZ6102	7.6066
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	XAV939	44.3323
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	XAV939	33.569
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	MN-64	131.89
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	WIKI4	31.513
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	AZ6102	7.9393
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	XAV939	2.3655
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	XAV939	32.553
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	MN-64	82.765
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	WIKI4	38.808
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	AZ6102	3.3947
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	XAV939	22.71
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	XAV939	71.998
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	MN-64	83.323
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	WIKI4	13.255
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	AZ6102	3.1757
SIDM00648	SCLC\|lung_small_cell_carcinoma	p.R60L (Yes)	GDSC	XAV939	78.1745
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	XAV939	7.4473
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	XAV939	28.116
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	MN-64	52.715
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	WIKI4	26.041
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	AZ6102	8.0552
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	XAV939	71.1269
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	XAV939	153.76
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	MN-64	205.78
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	WIKI4	102.73
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	AZ6102	3.0687
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	XAV939	14.8095
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	XAV939	47.362
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	MN-64	35.537
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	WIKI4	16.865
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	XAV939	5.2245
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	XAV939	40.786
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	MN-64	73.469
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	WIKI4	28.482
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	AZ6102	8.7542
SIDM00043	HNSC\|head_and_neck	p.E826K (No)	GDSC	XAV939	8.1249
SIDM00043	HNSC\|head_and_neck	p.E826K (No)	GDSC	XAV939	39.379
SIDM00043	HNSC\|head_and_neck	p.E826K (No)	GDSC	MN-64	42.267
SIDM00193	COREAD\|large_intestine	p.L1079* (No)	GDSC	XAV939	110.2345
SIDM00193	COREAD\|large_intestine	p.L1079* (No)	GDSC	XAV939	122.62
SIDM00193	COREAD\|large_intestine	p.L1079* (No)	GDSC	MN-64	124.55
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	XAV939	26.3981
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	XAV939	83.192
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	MN-64	659.92
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	WIKI4	33.349
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	AZ6102	23.748

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPFASPRHGLAL

Degron related mutations and impact score

Drug responses associated with TNKS mutations

All proteins holding degron of LAPFASPRHGLAL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_ODPH_VHL_1	53:65	LAPFASPRHGLAL	VHL	0.9838	More...