DegronMD

Uniprot ID: O95271

Source protein: Poly [ADP-ribose] polymerase tankyrase-1

Source gene: TNKS

Class: DEG_SPOP_SBC_1

Location: 135:139

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 72.32

COIL: 0.8596

CONS_SCORE: 0.2287

DSS_SCORE: 0.642

HELIX: 0.1118

FCONS_SCORE: 1.1644

RIG_SCORE: 0.4058

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S139T	TCGA-04-1649	OV	TCGA	PTSSS	DEG_SPOP_SBC_1	0.6005
p.S139T	DO32467	OV	ICGC	PTSSS	DEG_SPOP_SBC_1	0.6005
p.S139L	TCGA-04-1649	OV	TCGA	PTSSS	DEG_SPOP_SBC_1	0.7667
p.S139L	TCGA-DK-A3IN	BLCA	TCGA	PTSSS	DEG_SPOP_SBC_1	0.7667
p.S139L	DO455	BLCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.7667
p.S139L	DO32467	OV	ICGC	PTSSS	DEG_SPOP_SBC_1	0.7667
p.S134F	TCGA-A2-A0CR	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	0.3056
p.S134F	DO44163	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.3056
p.R146Q	ACH-000986	Colon/Colorectal Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	0.1389
p.R146Q	HT-115	large_intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.1389

Drug responses associated with TNKS mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Q1325H (No)	GDSC	XAV939	85.987
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	XAV939	70.6467
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	XAV939	291.17
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	MN-64	230.21
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	WIKI4	40.489
SIDM00533	PAAD\|pancreas	p.H12N (No)	GDSC	AZ6102	88.198
SIDM00839	COREAD\|large_intestine	p.S134delS (Yes)	GDSC	XAV939	31.9722
SIDM00839	COREAD\|large_intestine	p.S134delS (Yes)	GDSC	XAV939	198.58
SIDM00839	COREAD\|large_intestine	p.S134delS (Yes)	GDSC	MN-64	248.22
SIDM00839	COREAD\|large_intestine	p.S134delS (Yes)	GDSC	WIKI4	148.93
SIDM00839	COREAD\|large_intestine	p.S134delS (Yes)	GDSC	AZ6102	7.1508
SIDM00578	NB\|neuroblastoma	p.A599T (No)	GDSC	XAV939	62.2554
SIDM00578	NB\|neuroblastoma	p.A599T (No)	GDSC	WIKI4	12.557
SIDM00578	NB\|neuroblastoma	p.A599T (No)	GDSC	AZ6102	63.59
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R383K (No)	GDSC	XAV939	79.3525
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R383K (No)	GDSC	WIKI4	24.51
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R383K (No)	GDSC	AZ6102	34.542
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.H705R (No)	GDSC	XAV939	26.3351
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	XAV939	23.2978
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	XAV939	15.182
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	MN-64	29.879
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	WIKI4	9.4223
SIDM00151	OV\|ovary	p.R683Q (No)	GDSC	AZ6102	1.6334
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	XAV939	16.9117
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	XAV939	100.54
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	MN-64	64.865
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	WIKI4	34.912
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1180C (No)	GDSC	AZ6102	7.9351
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	XAV939	54.1713
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	XAV939	660.46
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	MN-64	266.56
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	WIKI4	77.804
SIDM00455	PAAD\|pancreas	p.A1323T (No)	GDSC	AZ6102	105.5
SIDM00550	ESCA\|oesophagus	p.G122S (No)	GDSC	XAV939	50.7815
SIDM00550	ESCA\|oesophagus	p.G122S (No)	GDSC	XAV939	77.275
SIDM00550	ESCA\|oesophagus	p.G122S (No)	GDSC	MN-64	140.69
SIDM00550	ESCA\|oesophagus	p.G122S (No)	GDSC	WIKI4	35.27
SIDM00550	ESCA\|oesophagus	p.G122S (No)	GDSC	AZ6102	9.8282
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.L807F (No)	GDSC	XAV939	31.6494
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.L807F (No)	GDSC	XAV939	92.715
SIDM00524	SCLC\|lung_small_cell_carcinoma	p.L807F (No)	GDSC	MN-64	91.757
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	XAV939	28.1116
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	XAV939	247.6
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	MN-64	118.17
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	WIKI4	39.52
SIDM00453	PAAD\|pancreas	p.K1157R (No)	GDSC	AZ6102	16.971
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	XAV939	45.6414
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	XAV939	31.094
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	MN-64	103.44
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	WIKI4	26.656
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.S1264G (No)	GDSC	AZ6102	10.89
SIDM00466	OV\|ovary	p.G1026V (No)	GDSC	XAV939	251.4354
SIDM00466	OV\|ovary	p.G1026V (No)	GDSC	WIKI4	96.525
SIDM00466	OV\|ovary	p.G1026V (No)	GDSC	AZ6102	544.64
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	XAV939	13.7175
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	XAV939	32.643
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	MN-64	31.387
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	WIKI4	37.338
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T508fs*33 (No)	GDSC	AZ6102	3.084
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	XAV939	43.9755
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	XAV939	84.099
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	MN-64	267.11
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	WIKI4	38.357
SIDM01090	COREAD\|large_intestine	p.I1068M (No)	GDSC	AZ6102	7.2998
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	XAV939	18.2292
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	XAV939	110.15
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	MN-64	201.25
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	WIKI4	25.204
SIDM00498	COREAD\|large_intestine	p.F436L (No)	GDSC	AZ6102	9.7102
SIDM01133	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A117P (No)	GDSC	XAV939	22.0108
SIDM01133	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A117P (No)	GDSC	WIKI4	136.35
SIDM01133	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A117P (No)	GDSC	AZ6102	5.2125
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.S726L (No)	GDSC	XAV939	59.5866
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	XAV939	109.662
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	XAV939	119.18
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	MN-64	235.8
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	WIKI4	26.924
SIDM01045	UCEC\|endometrium	p.K1326N (No)	GDSC	AZ6102	11.064
SIDM00303	OV\|ovary	p.S91I (No)	GDSC	XAV939	7.3161
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	XAV939	17.7995
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	XAV939	55.072
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	MN-64	97.883
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	WIKI4	32.948
SIDM00333	UCEC\|endometrium	p.C427F (No)	GDSC	AZ6102	5.8907
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	XAV939	33.12
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	XAV939	47.82
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	MN-64	139.06
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	WIKI4	23.719
SIDM00077	HNSC\|head_and_neck	p.L995F (No)	GDSC	AZ6102	13.248
SIDM00217	COREAD\|large_intestine	p.A1269V (No)	GDSC	XAV939	56.0028
SIDM00217	COREAD\|large_intestine	p.A1269V (No)	GDSC	XAV939	87.794
SIDM00217	COREAD\|large_intestine	p.A1269V (No)	GDSC	MN-64	234.76
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (Yes)	GDSC	XAV939	9.9121
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (Yes)	GDSC	XAV939	40.346
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (Yes)	GDSC	MN-64	41.058
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (Yes)	GDSC	WIKI4	44.377
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.P129S (Yes)	GDSC	AZ6102	10.693
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	XAV939	30.058
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	XAV939	14.922
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	MN-64	41.348
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	WIKI4	64.865
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.V202A (No)	GDSC	AZ6102	6.1498
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	XAV939	127.0465
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	XAV939	72.076
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	MN-64	234.68
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	WIKI4	65.973
SIDM00282	COREAD\|large_intestine	p.V666E (No)	GDSC	AZ6102	81.504
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	XAV939	32.0149
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	XAV939	197.08
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	MN-64	245.83
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	WIKI4	27.828
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.I1080M (No)	GDSC	AZ6102	10.241
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	XAV939	33.488
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	XAV939	21.277
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	MN-64	39.347
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	WIKI4	40.521
SIDM00888	MB\|medulloblastoma	p.K1157R (No)	GDSC	AZ6102	24.862
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	XAV939	40.0201
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	XAV939	167.43
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	MN-64	140.28
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	WIKI4	89.924
SIDM00660	COREAD\|large_intestine	p.L301P (No)	GDSC	AZ6102	9.804
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	XAV939	40.0201
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	XAV939	167.43
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	MN-64	140.28
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	WIKI4	89.924
SIDM00660	COREAD\|large_intestine	p.H925Y (No)	GDSC	AZ6102	9.804
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	XAV939	40.0201
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	XAV939	167.43
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	MN-64	140.28
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	WIKI4	89.924
SIDM00660	COREAD\|large_intestine	p.A1025V (No)	GDSC	AZ6102	9.804
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.H859R (No)	GDSC	XAV939	20.6881
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.H859R (No)	GDSC	WIKI4	43.494
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.H859R (No)	GDSC	AZ6102	12.367
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	XAV939	38.9965
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	XAV939	93.678
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	MN-64	81.255
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	WIKI4	44.17
SIDM00783	COREAD\|large_intestine	p.E734K (No)	GDSC	AZ6102	9.9173
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	XAV939	18.5747
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	XAV939	48.075
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	MN-64	81.085
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	WIKI4	36.023
SIDM00973	SKCM\|melanoma	p.R608C (No)	GDSC	AZ6102	6.1789
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	XAV939	100.4499
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	XAV939	71.743
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	MN-64	270.02
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	WIKI4	41.636
SIDM00359	COREAD\|large_intestine	p.P1095T (No)	GDSC	AZ6102	5.0573
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.I310V (No)	GDSC	XAV939	27.5392
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.H1100L (No)	GDSC	XAV939	59.9957
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.M584L (No)	GDSC	XAV939	60.9642
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.M584L (No)	GDSC	XAV939	63.82
SIDM00263	UNCLASSIFIED\|ewings_sarcoma	p.M584L (No)	GDSC	MN-64	79.419
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	XAV939	61.4203
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	XAV939	30.454
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	MN-64	168.26
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	WIKI4	49.78
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V195M (No)	GDSC	AZ6102	10.625
SIDM00534	COREAD\|large_intestine	p.R383* (No)	GDSC	XAV939	61.5614
SIDM00534	COREAD\|large_intestine	p.R383* (No)	GDSC	XAV939	188.95
SIDM00534	COREAD\|large_intestine	p.R383* (No)	GDSC	MN-64	172.11
SIDM00534	COREAD\|large_intestine	p.R383Q (No)	GDSC	XAV939	61.5614
SIDM00534	COREAD\|large_intestine	p.R383Q (No)	GDSC	XAV939	188.95
SIDM00534	COREAD\|large_intestine	p.R383Q (No)	GDSC	MN-64	172.11
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	XAV939	102.427
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	XAV939	169.39
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	MN-64	69.824
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	WIKI4	26.953
SIDM00487	COREAD\|large_intestine	p.D804fs*49 (No)	GDSC	AZ6102	33.407
SIDM00217	COREAD\|large_intestine	p.T508fs*33 (No)	GDSC	XAV939	56.0028
SIDM00217	COREAD\|large_intestine	p.T508fs*33 (No)	GDSC	XAV939	87.794
SIDM00217	COREAD\|large_intestine	p.T508fs*33 (No)	GDSC	MN-64	234.76
SIDM00191	KIRC\|kidney	p.A920T (No)	GDSC	XAV939	19.8717
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	XAV939	34.6906
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	XAV939	55.059
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	MN-64	139.07
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	WIKI4	146.88
SIDM00142	UCEC\|endometrium	p.T508fs*33 (No)	GDSC	AZ6102	59.89
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	XAV939	19.908
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	XAV939	42.133
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	MN-64	86.954
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	WIKI4	21.708
SIDM00994	ALL\|T_cell_leukemia	p.N1175S (No)	GDSC	AZ6102	6.0872
SIDM00120	PRAD\|prostate	p.G68V (No)	GDSC	XAV939	2.9243
SIDM00120	PRAD\|prostate	p.G68V (No)	GDSC	XAV939	273.2
SIDM00120	PRAD\|prostate	p.G68V (No)	GDSC	MN-64	309.57
SIDM00120	PRAD\|prostate	p.G68V (No)	GDSC	WIKI4	104.93
SIDM00120	PRAD\|prostate	p.G68V (No)	GDSC	AZ6102	83.293
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	XAV939	10.7811
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	XAV939	75.35
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	MN-64	32.346
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	WIKI4	34.56
SIDM00241	BRCA\|breast	p.F222L (No)	GDSC	AZ6102	21.284
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	XAV939	9.766
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	XAV939	29.351
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	MN-64	58.577
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	WIKI4	4.6635
SIDM00616	LIHC\|liver	p.V1004I (No)	GDSC	AZ6102	4.3586
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	XAV939	24.5716
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	XAV939	90.205
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	MN-64	191.54
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	WIKI4	72.138
SIDM00528	BRCA\|breast	p.G332V (No)	GDSC	AZ6102	11.373
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	XAV939	26.8047
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	XAV939	65.54
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	MN-64	166.58
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	WIKI4	46.604
SIDM00980	STAD\|stomach	p.N555fs*2 (No)	GDSC	AZ6102	7.6066
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	XAV939	44.3323
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	XAV939	33.569
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	MN-64	131.89
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	WIKI4	31.513
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.H13Q (No)	GDSC	AZ6102	7.9393
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	XAV939	2.3655
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	XAV939	32.553
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	MN-64	82.765
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	WIKI4	38.808
SIDM00373	UCEC\|endometrium	p.L976V (No)	GDSC	AZ6102	3.3947
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	XAV939	22.71
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	XAV939	71.998
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	MN-64	83.323
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	WIKI4	13.255
SIDM01076	UNCLASSIFIED\|lymphoblastic_leukemia	p.D296E (No)	GDSC	AZ6102	3.1757
SIDM00648	SCLC\|lung_small_cell_carcinoma	p.R60L (No)	GDSC	XAV939	78.1745
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	XAV939	7.4473
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	XAV939	28.116
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	MN-64	52.715
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	WIKI4	26.041
SIDM00942	HNSC\|head_and_neck	p.R383T (No)	GDSC	AZ6102	8.0552
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	XAV939	71.1269
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	XAV939	153.76
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	MN-64	205.78
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	WIKI4	102.73
SIDM00291	SKCM\|melanoma	p.A169S (No)	GDSC	AZ6102	3.0687
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	XAV939	14.8095
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	XAV939	47.362
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	MN-64	35.537
SIDM00837	COREAD\|large_intestine	p.A817V (No)	GDSC	WIKI4	16.865
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	XAV939	5.2245
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	XAV939	40.786
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	MN-64	73.469
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	WIKI4	28.482
SIDM00278	ESCA\|oesophagus	p.K715N (No)	GDSC	AZ6102	8.7542
SIDM00043	HNSC\|head_and_neck	p.E826K (No)	GDSC	XAV939	8.1249
SIDM00043	HNSC\|head_and_neck	p.E826K (No)	GDSC	XAV939	39.379
SIDM00043	HNSC\|head_and_neck	p.E826K (No)	GDSC	MN-64	42.267
SIDM00193	COREAD\|large_intestine	p.L1079* (No)	GDSC	XAV939	110.2345
SIDM00193	COREAD\|large_intestine	p.L1079* (No)	GDSC	XAV939	122.62
SIDM00193	COREAD\|large_intestine	p.L1079* (No)	GDSC	MN-64	124.55
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	XAV939	26.3981
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	XAV939	83.192
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	MN-64	659.92
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	WIKI4	33.349
SIDM00472	OV\|ovary	p.R678G (No)	GDSC	AZ6102	23.748

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	833:837	PTSSS	SPOP	0.988	More...
O14795	Protein unc-13 homolog B	DEG_SPOP_SBC_1	255:259	PTSSS	SPOP	0.9982	More...
O15353	Forkhead box protein N1	DEG_SPOP_SBC_1	566:570	PTSSS	SPOP	0.9933	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	135:139	PTSSS	SPOP	0.9984	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	306:310	PTSSS	SPOP	0.9982	More...
P50402	Emerin	DEG_SPOP_SBC_1	183:187	PTSSS	SPOP	0.9908	More...
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	DEG_SPOP_SBC_1	470:474	PTSSS	SPOP	0.9605	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	183:187	PTSSS	SPOP	0.896	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1874:1878	PTSSS	SPOP	0.8129	More...
Q05823	2-5A-dependent ribonuclease	DEG_SPOP_SBC_1	13:17	PTSSS	SPOP	0.9874	More...
Q10571	Transcriptional activator MN1	DEG_SPOP_SBC_1	1138:1142	PTSSS	SPOP	0.9495	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2626:2630	PTSSS	SPOP	0.9845	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	2377:2381	PTSSS	SPOP	0.9821	More...
Q2QGD7	Zinc finger protein ZXDC	DEG_SPOP_SBC_1	640:644	PTSSS	SPOP	0.9976	More...
Q4VCS5	Angiomotin	DEG_SPOP_SBC_1	211:215	PTSSS	SPOP	0.9988	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1276:1280	PTSSS	SPOP	0.9503	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	742:746	PTSSS	SPOP	0.9157	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1268:1272	PTSSS	SPOP	0.9958	More...
Q6NTF9	Rhomboid domain-containing protein 2	DEG_SPOP_SBC_1	314:318	PTSSS	SPOP	0.9747	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	377:381	PTSSS	SPOP	0.9915	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_SPOP_SBC_1	166:170	PTSSS	SPOP	0.9809	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	1195:1199	PTSSS	SPOP	0.9915	More...
Q8WUH2	Transforming growth factor-beta receptor-associated protein 1	DEG_SPOP_SBC_1	392:396	PTSSS	SPOP	0.6471	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	139:143	PTSSS	SPOP	0.948	More...
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_SPOP_SBC_1	923:927	PTSSS	SPOP	0.9994	More...
Q92934	Bcl2-associated agonist of cell death	DEG_SPOP_SBC_1	55:59	PTSSS	SPOP	0.7818	More...
Q9BUH8	Brain-enriched guanylate kinase-associated protein	DEG_SPOP_SBC_1	295:299	PTSSS	SPOP	0.9553	More...
Q9C0A1	Zinc finger homeobox protein 2	DEG_SPOP_SBC_1	2319:2323	PTSSS	SPOP	0.9971	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	2379:2383	PTSSS	SPOP	0.9083	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	17:21	PTSSS	SPOP	0.8669	More...
Q9Y5N1	Histamine H3 receptor	DEG_SPOP_SBC_1	303:307	PTSSS	SPOP	0.9912	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	657:661	PTSSS	SPOP	0.9681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSSS

Degron related mutations and impact score

Drug responses associated with TNKS mutations

All proteins holding degron of PTSSS