DegronMD - Q2QGD7(ZXDC)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L486P	TCGA-55-A494	LUAD	TCGA	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.1667
p.L486P	DO23794	LUAD	ICGC	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.1667
p.L482I	TCGA-A5-A0G2	UCEC	TCGA	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.0556
p.L482I	DO41235	UCEC	ICGC	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.0556
p.L482I	ACH-000954	Endometrial/Uterine Cancer	CCLE	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.0556
p.S651N	TCGA-A5-A2K3	UCEC	TCGA	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7069
p.S651N	DO43899	UCEC	ICGC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7069
p.P484H	TCGA-AA-3845	COAD	TCGA	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.1111
p.P484H	DO10020	COAD	ICGC	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.1111
p.S643L	TCGA-AN-A046	BRCA	TCGA	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	TCGA-AN-A046	BRCA	TCGA	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	TCGA-AN-A046	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	DO1285	BRCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	DO1285	BRCA	ICGC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	DO1285	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00993	Plasma Cell Myeloma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00993	Plasma Cell Myeloma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00993	Plasma Cell Myeloma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM01151	Hepatocellular Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM01151	Hepatocellular Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM01151	Hepatocellular Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00617	Hepatocellular Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00617	Hepatocellular Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00617	Hepatocellular Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM01145	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM01145	Gastric Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM01145	Gastric Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00301	Pancreatic Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00301	Pancreatic Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00301	Pancreatic Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00383	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00383	Gastric Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00383	Gastric Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00574	Glioblastoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00574	Glioblastoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00574	Glioblastoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00591	Oral Cavity Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00591	Oral Cavity Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00591	Oral Cavity Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00531	Pancreatic Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00531	Pancreatic Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00531	Pancreatic Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM01463	Endometrial Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM01463	Endometrial Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM01463	Endometrial Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM01617	Endometrial Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM01617	Endometrial Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM01617	Endometrial Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM01412	Oral Cavity Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM01412	Oral Cavity Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM01412	Oral Cavity Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00163	Biliary Tract Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00163	Biliary Tract Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00163	Biliary Tract Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM01445	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM01445	Gastric Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM01445	Gastric Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM00164	Biliary Tract Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM00164	Biliary Tract Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM00164	Biliary Tract Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.S643L	SIDM01753	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7667
p.S643L	SIDM01753	Gastric Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.7667
p.S643L	SIDM01753	Gastric Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7667
p.P489L	TCGA-EB-A3XB	SKCM	TCGA	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.25
p.P489L	DO37856	SKCM	ICGC	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.25
p.S642F	TCGA-W3-AA1R	SKCM	TCGA	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.6871
p.S642F	TCGA-W3-AA1R	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7982
p.S642F	DO51275	SKCM	ICGC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.6871
p.S642F	DO51275	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation altering degron motif	0.7982
p.A650V	DO230326	COCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.5825
p.L506F	DO233749	GACA	ICGC	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.0833
p.S500C	DO228199	LICA	ICGC	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.25
p.P46S	DO220857	MELA	ICGC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation rewiring degron network	0.2778
p.P653Q	DO27911	ORCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation altering degron motif	0.7035
p.N630T	DO36556	READ	ICGC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation rewiring degron network	0.1389
p.N630T	DO36556	READ	ICGC	PTSSS	DEG_SPOP_SBC_1	640:644	Mutation rewiring degron network	0.0556
p.G52R	DO219881	SKCA	ICGC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation rewiring degron network	0.1111
p.P658S	DO219878	SKCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation rewiring degron network	0.25
p.S495C	DO229253	THCA	ICGC	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation altering degron motif	0.643
p.G502D	DO229221	THCA	ICGC	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.1944
p.L482F	DO229248	THCA	ICGC	LTPSSE	DEG_SCF_FBW7_2	492:497	Mutation rewiring degron network	0.0556
p.A53E	SIDM00087	Plasma Cell Myeloma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation rewiring degron network	0.0833
p.A53E	SIDM00860	Head and Neck Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation rewiring degron network	0.0833
p.A53E	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation rewiring degron network	0.0833
p.A53E	SIDM00954	Breast Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation rewiring degron network	0.0833
p.A53E	SIDM00721	Small Cell Lung Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation rewiring degron network	0.0833
p.A53E	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation rewiring degron network	0.0833
p.A53E	SIDM01318	Hepatocellular Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation rewiring degron network	0.0833
p.R37H	SIDM00217	Colorectal Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation altering degron motif	0.8244
p.T638I	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.5966
p.T638I	ACH-000282	Lung Cancer	CCLE	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.5966
p.T638I	NCI-H1755	lung	COSMIC	ITTPTSS	DEG_SCF_FBW7_1	637:643	Mutation altering degron motif	0.5966
p.P51S	SIDM00540	Oral Cavity Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	36:44	Mutation rewiring degron network	0.1389
p.K660R	ACH-001522	Skin Cancer	CCLE	SSTPRENASVPEL	DEG_COP1_1	643:655	Mutation substituting flanking lysine	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZXDC

UniProt ID: Q2QGD7

Entrez ID: 79364

Protein name: Zinc finger protein ZXDC (ZXD-like zinc finger protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZXDC in