DegronMD

Uniprot ID: Q2QGD7

Source protein: Zinc finger protein ZXDC

Source gene: ZXDC

Class: DEG_SCF_FBW7_2

Location: 492:497

E3 ligase: FBXW7

DEGRON score: 0.9943

ASA_SCORE: 75.2167

COIL: 0.8065

CONS_SCORE: 0.3391

DSS_SCORE: 0.6911

HELIX: 0.0657

FCONS_SCORE: 1.0724

RIG_SCORE: 0.5835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L486P	TCGA-55-A494	LUAD	TCGA	LTPSSE	DEG_SCF_FBW7_2	0.1667
p.L486P	DO23794	LUAD	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.1667
p.L482I	TCGA-A5-A0G2	UCEC	TCGA	LTPSSE	DEG_SCF_FBW7_2	0.0556
p.L482I	DO41235	UCEC	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.0556
p.L482I	ACH-000954	Endometrial/Uterine Cancer	CCLE	LTPSSE	DEG_SCF_FBW7_2	0.0556
p.P484H	TCGA-AA-3845	COAD	TCGA	LTPSSE	DEG_SCF_FBW7_2	0.1111
p.P484H	DO10020	COAD	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.1111
p.P489L	TCGA-EB-A3XB	SKCM	TCGA	LTPSSE	DEG_SCF_FBW7_2	0.25
p.P489L	DO37856	SKCM	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.25
p.L506F	DO233749	GACA	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.0833
p.S500C	DO228199	LICA	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.25
p.S495C	DO229253	THCA	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.643
p.G502D	DO229221	THCA	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.1944
p.L482F	DO229248	THCA	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2QGD7	Zinc finger protein ZXDC	DEG_SCF_FBW7_2	492:497	LTPSSE	FBXW7	0.9943	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SCF_FBW7_2	588:593	LTPSSE	FBXW7	0.907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons