DegronMD

Uniprot ID: P98169

Source protein: Zinc finger X-linked protein ZXDB

Source gene: ZXDB

Class: DEG_SCF_FBW7_2

Location: 588:593

E3 ligase: FBXW7

DEGRON score: 0.907

ASA_SCORE: 68.4

COIL: 0.6938

CONS_SCORE: 0.5505

DSS_SCORE: 0.5182

HELIX: 0.1132

FCONS_SCORE: 1.2619

RIG_SCORE: 0.6795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R598T	TCGA-24-2262	OV	TCGA	LTPSSE	DEG_SCF_FBW7_2	0.1944
p.R598T	DO28843	OV	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.1944
p.S596I	TCGA-AP-A059	UCEC	TCGA	LTPSSE	DEG_SCF_FBW7_2	0.25
p.S596I	DO41361	UCEC	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.25
p.S596N	TCGA-AX-A064	UCEC	TCGA	LTPSSE	DEG_SCF_FBW7_2	0.25
p.S596N	DO43073	UCEC	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.25
p.A585S	TCGA-BK-A6W4	UCEC	TCGA	LTPSSE	DEG_SCF_FBW7_2	0.25
p.A585S	DO50077	UCEC	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.25
p.A584T	TCGA-DU-8158	LGG	TCGA	LTPSSE	DEG_SCF_FBW7_2	0.2222
p.A584T	DO22413	LGG	ICGC	LTPSSE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2QGD7	Zinc finger protein ZXDC	DEG_SCF_FBW7_2	492:497	LTPSSE	FBXW7	0.9943	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SCF_FBW7_2	588:593	LTPSSE	FBXW7	0.907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons