DegronMD

Uniprot ID: Q2QGD7

Source protein: Zinc finger protein ZXDC

Source gene: ZXDC

Class: DEG_APCC_DBOX_1

Location: 36:44

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5924

ASA_SCORE: 94.5778

COIL: 0.5402

CONS_SCORE: 0.3619

DSS_SCORE: 0.7121

HELIX: 0.1961

FCONS_SCORE: 1.1886

RIG_SCORE: 0.7203

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P46S	DO220857	MELA	ICGC	ARRRLLLVR	DEG_APCC_DBOX_1	0.2778
p.G52R	DO219881	SKCA	ICGC	ARRRLLLVR	DEG_APCC_DBOX_1	0.1111
p.A53E	SIDM00087	Plasma Cell Myeloma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	0.0833
p.A53E	SIDM00860	Head and Neck Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	0.0833
p.A53E	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	0.0833
p.A53E	SIDM00954	Breast Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	0.0833
p.A53E	SIDM00721	Small Cell Lung Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	0.0833
p.A53E	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	0.0833
p.A53E	SIDM01318	Hepatocellular Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	0.0833
p.R37H	SIDM00217	Colorectal Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	0.8244
p.P51S	SIDM00540	Oral Cavity Carcinoma	GDSC	ARRRLLLVR	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2QGD7	Zinc finger protein ZXDC	DEG_APCC_DBOX_1	36:44	ARRRLLLVR	APC,CDC20,FZR1	0.5924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons