DegronMD

Uniprot ID: Q2QGD7

Source protein: Zinc finger protein ZXDC

Source gene: ZXDC

Class: DEG_SCF_FBW7_1

Location: 637:643

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 61.9143

COIL: 0.7536

CONS_SCORE: 0.4494

DSS_SCORE: 0.5678

HELIX: 0.0163

FCONS_SCORE: 1.3904

RIG_SCORE: 0.635

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S643L	TCGA-AN-A046	BRCA	TCGA	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	DO1285	BRCA	ICGC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00993	Plasma Cell Myeloma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM01151	Hepatocellular Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00617	Hepatocellular Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM01145	Gastric Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00301	Pancreatic Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00383	Gastric Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00574	Glioblastoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00591	Oral Cavity Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00531	Pancreatic Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM01463	Endometrial Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM01617	Endometrial Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM01412	Oral Cavity Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00163	Biliary Tract Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM01445	Gastric Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM00164	Biliary Tract Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S643L	SIDM01753	Gastric Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.7667
p.S642F	TCGA-W3-AA1R	SKCM	TCGA	ITTPTSS	DEG_SCF_FBW7_1	0.6871
p.S642F	DO51275	SKCM	ICGC	ITTPTSS	DEG_SCF_FBW7_1	0.6871
p.N630T	DO36556	READ	ICGC	ITTPTSS	DEG_SCF_FBW7_1	0.1389
p.T638I	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	ITTPTSS	DEG_SCF_FBW7_1	0.5966
p.T638I	ACH-000282	Lung Cancer	CCLE	ITTPTSS	DEG_SCF_FBW7_1	0.5966
p.T638I	NCI-H1755	lung	COSMIC	ITTPTSS	DEG_SCF_FBW7_1	0.5966

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITTPTSS

Degron related mutations and impact score

Drug responses associated with ZXDC mutations

All proteins holding degron of ITTPTSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2QGD7	Zinc finger protein ZXDC	DEG_SCF_FBW7_1	637:643	ITTPTSS	FBXW7	0.9971	More...