DegronMD

Uniprot ID: Q2QGD7

Source protein: Zinc finger protein ZXDC

Source gene: ZXDC

Class: DEG_COP1_1

Location: 643:655

E3 ligase: COP1

DEGRON score: 0.997

ASA_SCORE: 79.3231

COIL: 0.7299

CONS_SCORE: 0.3359

DSS_SCORE: 0.6375

HELIX: 0.2061

FCONS_SCORE: 1.0458

RIG_SCORE: 0.6468

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S643L	TCGA-AN-A046	BRCA	TCGA	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	DO1285	BRCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00993	Plasma Cell Myeloma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01151	Hepatocellular Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00617	Hepatocellular Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01145	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00301	Pancreatic Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00383	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00574	Glioblastoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00591	Oral Cavity Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00531	Pancreatic Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01463	Endometrial Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01617	Endometrial Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01412	Oral Cavity Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00163	Biliary Tract Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01445	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00164	Biliary Tract Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01753	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S651N	TCGA-A5-A2K3	UCEC	TCGA	SSTPRENASVPEL	DEG_COP1_1	0.7069
p.S651N	DO43899	UCEC	ICGC	SSTPRENASVPEL	DEG_COP1_1	0.7069
p.P653Q	DO27911	ORCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	0.7035
p.A650V	DO230326	COCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	0.5825
p.K660R	ACH-001522	Skin Cancer	CCLE	SSTPRENASVPEL	DEG_COP1_1	0.3056

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Drug responses associated with ZXDC mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of SSTPRENASVPEL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2QGD7	Zinc finger protein ZXDC	DEG_COP1_1	643:655	SSTPRENASVPEL	COP1	0.997	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSTPRENASVPEL

Degron related mutations and impact score

Drug responses associated with ZXDC mutations

All proteins holding degron of SSTPRENASVPEL