DegronMD

Uniprot ID: Q2QGD7

Source protein: Zinc finger protein ZXDC

Source gene: ZXDC

Class: DEG_COP1_1

Location: 643:655

E3 ligase: COP1

DEGRON score: 0.997

ASA_SCORE: 79.3231

COIL: 0.7299

CONS_SCORE: 0.3359

DSS_SCORE: 0.6375

HELIX: 0.2061

FCONS_SCORE: 1.0458

RIG_SCORE: 0.6468

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S651N	TCGA-A5-A2K3	UCEC	TCGA	SSTPRENASVPEL	DEG_COP1_1	0.7069
p.S651N	DO43899	UCEC	ICGC	SSTPRENASVPEL	DEG_COP1_1	0.7069
p.S643L	TCGA-AN-A046	BRCA	TCGA	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	DO1285	BRCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00993	Plasma Cell Myeloma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01151	Hepatocellular Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00617	Hepatocellular Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01145	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00301	Pancreatic Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00383	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00574	Glioblastoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00591	Oral Cavity Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00531	Pancreatic Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01463	Endometrial Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01617	Endometrial Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01412	Oral Cavity Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00163	Biliary Tract Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01445	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM00164	Biliary Tract Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.S643L	SIDM01753	Gastric Carcinoma	GDSC	SSTPRENASVPEL	DEG_COP1_1	0.7667
p.A650V	DO230326	COCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	0.5825
p.P653Q	DO27911	ORCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	0.7035
p.P658S	DO219878	SKCA	ICGC	SSTPRENASVPEL	DEG_COP1_1	0.25
p.K660R	ACH-001522	Skin Cancer	CCLE	SSTPRENASVPEL	DEG_COP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSTPRENASVPEL

Degron related mutations and impact score

Drug responses associated with ZXDC mutations

All proteins holding degron of SSTPRENASVPEL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2QGD7	Zinc finger protein ZXDC	DEG_COP1_1	643:655	SSTPRENASVPEL	COP1	0.997	More...