DegronMD

Uniprot ID: Q8WWN8

Source protein: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Source gene: ARAP3

Class: DEG_SPOP_SBC_1

Location: 139:143

E3 ligase: SPOP

DEGRON score: 0.948

ASA_SCORE: 80.6

COIL: 0.8786

CONS_SCORE: 0.3603

DSS_SCORE: 0.7708

HELIX: 0.105

FCONS_SCORE: 0.9602

RIG_SCORE: 0.545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S141F	TCGA-05-4382	LUAD	TCGA	PTSSS	DEG_SPOP_SBC_1	0.7982
p.S141F	DO24900	LUAD	ICGC	PTSSS	DEG_SPOP_SBC_1	0.7982
p.P129A	TCGA-B6-A0X1	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	0.0556
p.P129A	DO4854	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.0556
p.P136S	TCGA-EE-A3AA	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	0.25
p.P136S	DO222632	MELA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.25
p.P136S	DO37571	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	0.25
p.P136L	DO218269	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.25
p.E152K	DO233249	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.0833
p.R133Q	DO233267	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.1667
p.P135H	DO229018	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	0.2222
p.W136C	DO23574	LUAD	ICGC	PTSSS	DEG_SPOP_SBC_1	0.25
p.G130V	DO51965	PRAD	ICGC	PTSSS	DEG_SPOP_SBC_1	0.0833
p.P137H	SIDM00660	Colorectal Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	0.2778
p.P137H	LS-411N	large_intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.2778
p.R142K	ACH-000874	Leukemia	CCLE	PTSSS	DEG_SPOP_SBC_1	0.7237
p.R142K	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.7237
p.V133L	ACH-000900	Lung Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	0.1667
p.V133L	NCI-H23	lung	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.1667
p.E146K	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.25
p.W136R	JHH-1	liver	COSMIC	PTSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	833:837	PTSSS	SPOP	0.988	More...
O14795	Protein unc-13 homolog B	DEG_SPOP_SBC_1	255:259	PTSSS	SPOP	0.9982	More...
O15353	Forkhead box protein N1	DEG_SPOP_SBC_1	566:570	PTSSS	SPOP	0.9933	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	135:139	PTSSS	SPOP	0.9984	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	306:310	PTSSS	SPOP	0.9982	More...
P50402	Emerin	DEG_SPOP_SBC_1	183:187	PTSSS	SPOP	0.9908	More...
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	DEG_SPOP_SBC_1	470:474	PTSSS	SPOP	0.9605	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	183:187	PTSSS	SPOP	0.896	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1874:1878	PTSSS	SPOP	0.8129	More...
Q05823	2-5A-dependent ribonuclease	DEG_SPOP_SBC_1	13:17	PTSSS	SPOP	0.9874	More...
Q10571	Transcriptional activator MN1	DEG_SPOP_SBC_1	1138:1142	PTSSS	SPOP	0.9495	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2626:2630	PTSSS	SPOP	0.9845	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	2377:2381	PTSSS	SPOP	0.9821	More...
Q2QGD7	Zinc finger protein ZXDC	DEG_SPOP_SBC_1	640:644	PTSSS	SPOP	0.9976	More...
Q4VCS5	Angiomotin	DEG_SPOP_SBC_1	211:215	PTSSS	SPOP	0.9988	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1276:1280	PTSSS	SPOP	0.9503	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	742:746	PTSSS	SPOP	0.9157	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1268:1272	PTSSS	SPOP	0.9958	More...
Q6NTF9	Rhomboid domain-containing protein 2	DEG_SPOP_SBC_1	314:318	PTSSS	SPOP	0.9747	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	377:381	PTSSS	SPOP	0.9915	More...
Q86YN6	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	DEG_SPOP_SBC_1	166:170	PTSSS	SPOP	0.9809	More...
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SPOP_SBC_1	1195:1199	PTSSS	SPOP	0.9915	More...
Q8WUH2	Transforming growth factor-beta receptor-associated protein 1	DEG_SPOP_SBC_1	392:396	PTSSS	SPOP	0.6471	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	139:143	PTSSS	SPOP	0.948	More...
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_SPOP_SBC_1	923:927	PTSSS	SPOP	0.9994	More...
Q92934	Bcl2-associated agonist of cell death	DEG_SPOP_SBC_1	55:59	PTSSS	SPOP	0.7818	More...
Q9BUH8	Brain-enriched guanylate kinase-associated protein	DEG_SPOP_SBC_1	295:299	PTSSS	SPOP	0.9553	More...
Q9C0A1	Zinc finger homeobox protein 2	DEG_SPOP_SBC_1	2319:2323	PTSSS	SPOP	0.9971	More...
Q9NYQ7	Cadherin EGF LAG seven-pass G-type receptor 3	DEG_SPOP_SBC_1	2379:2383	PTSSS	SPOP	0.9083	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	17:21	PTSSS	SPOP	0.8669	More...
Q9Y5N1	Histamine H3 receptor	DEG_SPOP_SBC_1	303:307	PTSSS	SPOP	0.9912	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	657:661	PTSSS	SPOP	0.9681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSSS

Degron related mutations and impact score

Drug responses associated with ARAP3 mutations

All proteins holding degron of PTSSS