DegronMD - Q6NTF9(RHBDD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G325C	TCGA-05-4427	LUAD	TCGA	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.1389
p.G325C	TCGA-05-4427	LUAD	TCGA	PTSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389
p.G325C	DO23666	LUAD	ICGC	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.1389
p.G325C	DO23666	LUAD	ICGC	PTSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389
p.P333L	TCGA-AP-A1DK	UCEC	TCGA	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation altering degron motif	0.6471
p.P333L	DO42033	UCEC	ICGC	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation altering degron motif	0.6471
p.S344Y	TCGA-AP-A1DV	UCEC	TCGA	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.1667
p.S344Y	DO43186	UCEC	ICGC	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.1667
p.T334M	TCGA-AX-A05Y	UCEC	TCGA	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation altering degron motif	0.7423
p.T334M	DO42897	UCEC	ICGC	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation altering degron motif	0.7423
p.G329V	TCGA-B0-4815	KIRC	TCGA	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.25
p.G329V	DO18661	KIRC	ICGC	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.25
p.S318G	TCGA-CG-5723	STAD	TCGA	PTSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6993
p.S318G	DO38376	STAD	ICGC	PTSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6993
p.V306L	TCGA-CV-A6JN	HNSC	TCGA	PTSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1111
p.V306L	DO49993	HNSC	ICGC	PTSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1111
p.S327F	TCGA-EE-A2A1	SKCM	TCGA	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.1944
p.S327F	TCGA-EE-A2A1	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0833
p.S327F	DO38045	SKCM	ICGC	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.1944
p.S327F	DO38045	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0833
p.P339S	TCGA-EE-A2MS	SKCM	TCGA	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.3056
p.P339S	DO37567	SKCM	ICGC	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.3056
p.P312L	TCGA-EE-A3JB	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.P312L	DO51250	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.L347S	TCGA-FI-A2D5	UCEC	TCGA	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.0833
p.L347S	DO41331	UCEC	ICGC	PPTPVNS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.0833

Kaplan plot for RHBDD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RHBDD2

UniProt ID: Q6NTF9

Entrez ID: 57414

Protein name: Rhomboid domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RHBDD2 in