DegronMD

Uniprot ID: Q6NTF9

Source protein: Rhomboid domain-containing protein 2

Source gene: RHBDD2

Class: DEG_SCF_FBW7_1

Location: 332:338

E3 ligase: FBXW7

DEGRON score: 0.9963

ASA_SCORE: 70.4714

COIL: 0.9241

CONS_SCORE: 0.3463

DSS_SCORE: 0.5165

HELIX: 0.0227

FCONS_SCORE: 0.7934

RIG_SCORE: 0.6364

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G325C	TCGA-05-4427	LUAD	TCGA	PPTPVNS	DEG_SCF_FBW7_1	0.1389
p.G325C	DO23666	LUAD	ICGC	PPTPVNS	DEG_SCF_FBW7_1	0.1389
p.P333L	TCGA-AP-A1DK	UCEC	TCGA	PPTPVNS	DEG_SCF_FBW7_1	0.6471
p.P333L	DO42033	UCEC	ICGC	PPTPVNS	DEG_SCF_FBW7_1	0.6471
p.S344Y	TCGA-AP-A1DV	UCEC	TCGA	PPTPVNS	DEG_SCF_FBW7_1	0.1667
p.S344Y	DO43186	UCEC	ICGC	PPTPVNS	DEG_SCF_FBW7_1	0.1667
p.T334M	TCGA-AX-A05Y	UCEC	TCGA	PPTPVNS	DEG_SCF_FBW7_1	0.7423
p.T334M	DO42897	UCEC	ICGC	PPTPVNS	DEG_SCF_FBW7_1	0.7423
p.G329V	TCGA-B0-4815	KIRC	TCGA	PPTPVNS	DEG_SCF_FBW7_1	0.25
p.G329V	DO18661	KIRC	ICGC	PPTPVNS	DEG_SCF_FBW7_1	0.25
p.S327F	TCGA-EE-A2A1	SKCM	TCGA	PPTPVNS	DEG_SCF_FBW7_1	0.1944
p.S327F	DO38045	SKCM	ICGC	PPTPVNS	DEG_SCF_FBW7_1	0.1944
p.P339S	TCGA-EE-A2MS	SKCM	TCGA	PPTPVNS	DEG_SCF_FBW7_1	0.3056
p.P339S	DO37567	SKCM	ICGC	PPTPVNS	DEG_SCF_FBW7_1	0.3056
p.L347S	TCGA-FI-A2D5	UCEC	TCGA	PPTPVNS	DEG_SCF_FBW7_1	0.0833
p.L347S	DO41331	UCEC	ICGC	PPTPVNS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NTF9	Rhomboid domain-containing protein 2	DEG_SCF_FBW7_1	332:338	PPTPVNS	FBXW7	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons