DegronMD - O15353(FOXN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P573A	TCGA-14-0866	GBM	TCGA	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.P573A	DO11878	GBM	ICGC	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.25
p.P492R	TCGA-14-1823	GBM	TCGA	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.3056
p.P492R	DO12070	GBM	ICGC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.3056
p.S570L	TCGA-74-6584	GBM	TCGA	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation altering degron motif	0.7667
p.S570L	DO12778	GBM	ICGC	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation altering degron motif	0.7667
p.S570L	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation altering degron motif	0.7667
p.S570L	ACH-000636	Leukemia	CCLE	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation altering degron motif	0.7667
p.S570L	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation altering degron motif	0.7667
p.L561R	TCGA-B5-A0JY	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1944
p.L561R	DO43041	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1944
p.Q489H	TCGA-C8-A1HJ	BRCA	TCGA	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation altering degron motif	0.647
p.Q489H	DO1464	BRCA	ICGC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation altering degron motif	0.647
p.S500I	TCGA-EE-A20F	SKCM	TCGA	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.0833
p.S500I	DO37961	SKCM	ICGC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.0833
p.P558S	TCGA-EE-A2MF	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1111
p.P558S	DO222491	MELA	ICGC	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1111
p.P558S	DO51249	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1111
p.R482Q	TCGA-EE-A2MR	SKCM	TCGA	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.25
p.R482Q	DO37819	SKCM	ICGC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.25
p.R482L	TCGA-GF-A2C7	SKCM	TCGA	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.25
p.R482L	DO37407	SKCM	ICGC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.25
p.H501Y	TCGA-WE-AAA3	SKCM	TCGA	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.0556
p.H501Y	DO51295	SKCM	ICGC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.0556
p.S564L	DO225046	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.2778
p.A495S	DO228985	LICA	ICGC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.2222
p.T497P	DO229499	SKCA	ICGC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.1667
p.G477R	SIDM01060	Melanoma	GDSC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.1111
p.G477R	ACH-000882	Skin Cancer	CCLE	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.1111
p.G477R	IGR-1	skin	COSMIC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.1111
p.P498S	SIDM01473	Plasma Cell Myeloma	GDSC	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.1389
p.P498S	ACH-000541	Myeloma	CCLE	PGTPQDS	DEG_SCF_FBW7_1	485:491	Mutation rewiring degron network	0.1389

Kaplan plot for FOXN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXN1

UniProt ID: O15353

Entrez ID: 8456

Protein name: Forkhead box protein N1 (Winged-helix transcription factor nude)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXN1 in