DegronMD

Uniprot ID: O15353

Source protein: Forkhead box protein N1

Source gene: FOXN1

Class: DEG_SCF_FBW7_1

Location: 485:491

E3 ligase: FBXW7

DEGRON score: 0.9872

ASA_SCORE: 71.4286

COIL: 0.9387

CONS_SCORE: 0.573

DSS_SCORE: 0.8588

HELIX: 0.0401

FCONS_SCORE: 1.0577

RIG_SCORE: 0.5151

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P492R	TCGA-14-1823	GBM	TCGA	PGTPQDS	DEG_SCF_FBW7_1	0.3056
p.P492R	DO12070	GBM	ICGC	PGTPQDS	DEG_SCF_FBW7_1	0.3056
p.Q489H	TCGA-C8-A1HJ	BRCA	TCGA	PGTPQDS	DEG_SCF_FBW7_1	0.647
p.Q489H	DO1464	BRCA	ICGC	PGTPQDS	DEG_SCF_FBW7_1	0.647
p.S500I	TCGA-EE-A20F	SKCM	TCGA	PGTPQDS	DEG_SCF_FBW7_1	0.0833
p.S500I	DO37961	SKCM	ICGC	PGTPQDS	DEG_SCF_FBW7_1	0.0833
p.R482Q	TCGA-EE-A2MR	SKCM	TCGA	PGTPQDS	DEG_SCF_FBW7_1	0.25
p.R482Q	DO37819	SKCM	ICGC	PGTPQDS	DEG_SCF_FBW7_1	0.25
p.R482L	TCGA-GF-A2C7	SKCM	TCGA	PGTPQDS	DEG_SCF_FBW7_1	0.25
p.R482L	DO37407	SKCM	ICGC	PGTPQDS	DEG_SCF_FBW7_1	0.25
p.H501Y	TCGA-WE-AAA3	SKCM	TCGA	PGTPQDS	DEG_SCF_FBW7_1	0.0556
p.H501Y	DO51295	SKCM	ICGC	PGTPQDS	DEG_SCF_FBW7_1	0.0556
p.A495S	DO228985	LICA	ICGC	PGTPQDS	DEG_SCF_FBW7_1	0.2222
p.T497P	DO229499	SKCA	ICGC	PGTPQDS	DEG_SCF_FBW7_1	0.1667
p.G477R	SIDM01060	Melanoma	GDSC	PGTPQDS	DEG_SCF_FBW7_1	0.1111
p.G477R	ACH-000882	Skin Cancer	CCLE	PGTPQDS	DEG_SCF_FBW7_1	0.1111
p.G477R	IGR-1	skin	COSMIC	PGTPQDS	DEG_SCF_FBW7_1	0.1111
p.P498S	SIDM01473	Plasma Cell Myeloma	GDSC	PGTPQDS	DEG_SCF_FBW7_1	0.1389
p.P498S	ACH-000541	Myeloma	CCLE	PGTPQDS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15353	Forkhead box protein N1	DEG_SCF_FBW7_1	485:491	PGTPQDS	FBXW7	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons