DegronMD - Q8WWN8(ARAP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S141F	TCGA-05-4382	LUAD	TCGA	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7982
p.S141F	DO24900	LUAD	ICGC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7982
p.P129A	TCGA-B6-A0X1	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.P129A	DO4854	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.P1532L	TCGA-D3-A8GI	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	1532:1536	Mutation altering degron motif	0.7582
p.P1532L	DO50284	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	1532:1536	Mutation altering degron motif	0.7582
p.P136S	TCGA-EE-A3AA	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.P136S	DO222632	MELA	ICGC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.P136S	DO37571	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.Q1523H	TCGA-EO-A3AU	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.0833
p.Q1523H	TCGA-EY-A1GD	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	1532:1536	Mutation rewiring degron network	0.0833
p.P136L	DO218269	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.E152K	DO233249	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R133Q	DO233267	GACA	ICGC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.P135H	DO229018	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.W136C	DO23574	LUAD	ICGC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.G130V	DO51965	PRAD	ICGC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.P137H	SIDM00660	Colorectal Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.P137H	LS-411N	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.R142K	ACH-000874	Leukemia	CCLE	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7237
p.R142K	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7237
p.V133L	ACH-000900	Lung Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.V133L	NCI-H23	lung	COSMIC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.E146K	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.W136R	JHH-1	liver	COSMIC	PTSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25

Kaplan plot for ARAP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARAP3

UniProt ID: Q8WWN8

Entrez ID: 64411

Protein name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARAP3 in