DegronMD

Uniprot ID: Q8WWN8

Source protein: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Source gene: ARAP3

Class: DEG_SPOP_SBC_1

Location: 1532:1536

E3 ligase: SPOP

DEGRON score: 0.9333

ASA_SCORE: 78.4

COIL: 0.9198

CONS_SCORE: 0.1103

DSS_SCORE: 0.8519

HELIX: 0.025

FCONS_SCORE: 0.9218

RIG_SCORE: 0.557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1532L	TCGA-D3-A8GI	SKCM	TCGA	PCTSS	DEG_SPOP_SBC_1	0.7582
p.P1532L	DO50284	SKCM	ICGC	PCTSS	DEG_SPOP_SBC_1	0.7582
p.Q1523H	TCGA-EO-A3AU	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.0833
p.Q1523H	TCGA-EY-A1GD	UCEC	TCGA	PCTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13952	Nuclear transcription factor Y subunit gamma	DEG_SPOP_SBC_1	344:348	PCTSS	SPOP	0.9867	More...
Q14140	SERTA domain-containing protein 2	DEG_SPOP_SBC_1	260:264	PCTSS	SPOP	0.9248	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1747:1751	PCTSS	SPOP	0.9941	More...
Q15916	Zinc finger and BTB domain-containing protein 6	DEG_SPOP_SBC_1	238:242	PCTSS	SPOP	0.9861	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1609:1613	PCTSS	SPOP	0.9968	More...
Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	1532:1536	PCTSS	SPOP	0.9333	More...
Q96H55	Unconventional myosin-XIX	DEG_SPOP_SBC_1	677:681	PCTSS	SPOP	0.8963	More...
Q9BZ71	Membrane-associated phosphatidylinositol transfer protein 3	DEG_SPOP_SBC_1	81:85	PCTSS	SPOP	0.9091	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	39:43	PCTSS	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons