DegronMD

Uniprot ID: Q9UQ26

Source protein: Regulating synaptic membrane exocytosis protein 2

Source gene: RIMS2

Class: DEG_SCF_FBW7_1

Location: 464:470

E3 ligase: FBXW7

DEGRON score: 0.9941

ASA_SCORE: 109.6714

COIL: 0.9783

CONS_SCORE: 0.4619

DSS_SCORE: 0.8437

HELIX: 0.0101

FCONS_SCORE: 1.1754

RIG_SCORE: 0.5476

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R471P	TCGA-64-5781	LUAD	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.3056
p.R471P	DO23740	LUAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.3056
p.H459Y	TCGA-73-A9RS	LUAD	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.1944
p.H459Y	DO51193	LUAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.1944
p.V466L	TCGA-85-8355	LUSC	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.6765
p.V466L	DO233091	GACA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.6765
p.V466L	DO45488	LUSC	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.6765
p.E475K	TCGA-90-A4ED	LUSC	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.1944
p.E475K	DO45482	LUSC	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.1944
p.S463G	TCGA-AP-A0LI	UCEC	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.75
p.S463G	DO43658	UCEC	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.75
p.S463R	TCGA-B5-A3FA	UCEC	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.75
p.S463R	DO52402	UCEC	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.75
p.R455Q	TCGA-BR-6452	STAD	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.0833
p.R455Q	TCGA-VQ-A91K	STAD	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.0833
p.R455Q	DO38404	STAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.0833
p.R455Q	DO51785	STAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.0833
p.V466A	TCGA-CN-4738	HNSC	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.6936
p.V466A	DO14214	HNSC	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.6936
p.E472K	TCGA-DA-A1HV	SKCM	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.2778
p.E472K	TCGA-FW-A3R5	SKCM	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.2778
p.E472K	DO220899	MELA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.2778
p.E472K	DO222395	MELA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.2778
p.E472K	DO37659	SKCM	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.2778
p.E472K	DO37406	SKCM	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.2778
p.P462S	TCGA-FS-A1ZK	SKCM	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.2778
p.P462S	DO37474	SKCM	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.2778
p.R479M	TCGA-FS-A1ZM	SKCM	TCGA	PPTPRRS	DEG_SCF_FBW7_1	0.0833
p.R479M	DO37731	SKCM	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.0833
p.D461Y	DO222849	COCA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.25
p.K468T	DO234311	ESAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.7306
p.N480T	DO234311	ESAD	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.0556
p.E472G	DO233732	GACA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.2778
p.R471W	DO220898	MELA	ICGC	PPTPRRS	DEG_SCF_FBW7_1	0.3056
p.H458N	SIDM00583	Pancreatic Carcinoma	GDSC	PPTPRRS	DEG_SCF_FBW7_1	0.1667
p.H458N	KP-1N	pancreas	COSMIC	PPTPRRS	DEG_SCF_FBW7_1	0.1667
p.K473N	SIDM00192	Colorectal Carcinoma	GDSC	PPTPRRS	DEG_SCF_FBW7_1	0.25
p.R455W	SIDM00162	Biliary Tract Carcinoma	GDSC	PPTPRRS	DEG_SCF_FBW7_1	0.0833
p.G469D	NCI-H661	lung	COSMIC	PPTPRRS	DEG_SCF_FBW7_1	0.7198
p.M465I	NCI-H520	lung	COSMIC	PPTPRRS	DEG_SCF_FBW7_1	0.7618
p.L470I	KYSE-140	oesophagus	COSMIC	PPTPRRS	DEG_SCF_FBW7_1	0.7174
p.L456Q	HCC70	breast	COSMIC	PPTPRRS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPRRS

Degron related mutations and impact score

Drug responses associated with RIMS2 mutations

All proteins holding degron of PPTPRRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ26	Regulating synaptic membrane exocytosis protein 2	DEG_SCF_FBW7_1	464:470	PPTPRRS	FBXW7	0.9941	More...