DegronMD

Uniprot ID: Q9UQ26

Source protein: Regulating synaptic membrane exocytosis protein 2

Source gene: RIMS2

Class: DEG_SCF_TRCP1_1

Location: 622:627

E3 ligase: BTRC

DEGRON score: 0.9851

ASA_SCORE: 70.7833

COIL: 0.8552

CONS_SCORE: 0.5615

DSS_SCORE: 0.5587

HELIX: 0.0843

FCONS_SCORE: 1.0704

RIG_SCORE: 0.6854

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S627R	TCGA-55-1592	LUAD	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.7427
p.S627R	DO234414	ESAD	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.7427
p.S627R	DO233679	GACA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.7427
p.S627R	DO23556	LUAD	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.7427
p.S613L	TCGA-AG-3583	READ	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.0833
p.S613L	DO36787	READ	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.0833
p.S613T	TCGA-AP-A1DV	UCEC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.0833
p.S613T	DO43186	UCEC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.0833
p.C617F	TCGA-BB-A5HY	HNSC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.1944
p.C617F	DO218979	HNSC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.1944
p.G626E	TCGA-D3-A3MU	SKCM	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.7199
p.G626E	DO47337	SKCM	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.7199
p.K625N	TCGA-DG-A2KK	CESC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.6918
p.K625N	DO51595	CESC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.6918
p.C617S	TCGA-DM-A28G	COAD	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.1944
p.C617S	DO10750	COAD	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.1944
p.R636K	TCGA-FR-A726	SKCM	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.0833
p.R636K	DO48665	SKCM	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.0833
p.R615W	TCGA-GF-A6C9	SKCM	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.1389
p.R615W	DO51254	SKCM	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.1389
p.P637T	TCGA-NC-A5HT	LUSC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.0556
p.P637T	DO219205	LUSC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.0556
p.I620V	TCGA-UB-A7ME	LIHC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.2778
p.I620V	DO52321	LIHC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.2778
p.K624N	DO8264	COAD	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.6918
p.L635V	DO222645	ESCA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.1111
p.E612V	DO233662	GACA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.0556
p.V632A	DO233747	GACA	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.1944
p.A629S	SIDM00583	Pancreatic Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	0.2778
p.A629S	KP-1N	pancreas	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	0.2778
p.G614D	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	0.1111
p.G614D	NCI-H661	lung	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	0.1111
p.A629V	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	0.2778
p.A629V	SK-LU-1	lung	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	0.2778
p.D630N	SIDM00685	Glioblastoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	0.25
p.D630N	LN-18	central_nervous_system	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	0.25
p.T631N	SIDM01503	Small Cell Lung Carcinoma	GDSC	DSGVDT	DEG_SCF_TRCP1_1	0.2222
p.P620S	H9	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	0.2778
p.R637I	HT-115	large_intestine	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	0.0556
p.L625I	NCI-H630	large_intestine	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	0.7174
p.N634Y	NCI-H2291	lung	COSMIC	DSGVDT	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8ND56	Protein LSM14 homolog A	DEG_SCF_TRCP1_1	339:344	DSGVDT	BTRC	0.9941	More...
Q92870	Amyloid beta precursor protein binding family B member 2	DEG_SCF_TRCP1_1	8:13	DSGVDT	BTRC	0.924	More...
Q9UQ26	Regulating synaptic membrane exocytosis protein 2	DEG_SCF_TRCP1_1	622:627	DSGVDT	BTRC	0.9851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGVDT

Degron related mutations and impact score

Drug responses associated with RIMS2 mutations

All proteins holding degron of DSGVDT