DegronMD

Uniprot ID: Q8ND56

Source protein: Protein LSM14 homolog A

Source gene: LSM14A

Class: DEG_SCF_TRCP1_1

Location: 339:344

E3 ligase: BTRC

DEGRON score: 0.9941

ASA_SCORE: 75.5333

COIL: 0.8525

CONS_SCORE: 0.3122

DSS_SCORE: 0.747

HELIX: 0.0898

FCONS_SCORE: 1.1088

RIG_SCORE: 0.6028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G334S	TCGA-D6-6516	HNSC	TCGA	DSGVDT	DEG_SCF_TRCP1_1	0.1944
p.G334S	DO15623	HNSC	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.1944
p.E335D	DO46432	OV	ICGC	DSGVDT	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8ND56	Protein LSM14 homolog A	DEG_SCF_TRCP1_1	339:344	DSGVDT	BTRC	0.9941	More...
Q92870	Amyloid beta precursor protein binding family B member 2	DEG_SCF_TRCP1_1	8:13	DSGVDT	BTRC	0.924	More...
Q9UQ26	Regulating synaptic membrane exocytosis protein 2	DEG_SCF_TRCP1_1	622:627	DSGVDT	BTRC	0.9851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons