DegronMD

Uniprot ID: Q9UQ26

Source protein: Regulating synaptic membrane exocytosis protein 2

Source gene: RIMS2

Class: DEG_APCC_DBOX_1

Location: 7:15

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9236

ASA_SCORE: 98.5889

COIL: 0.9584

CONS_SCORE: 0.2604

DSS_SCORE: 0.682

HELIX: 0.0198

FCONS_SCORE: 0.8313

RIG_SCORE: 0.6204

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A17D	TCGA-05-4382	LUAD	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	0.2778
p.A17D	DO24900	LUAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2778
p.R8L	TCGA-56-7822	LUSC	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	0.8428
p.R8L	DO26638	LUSC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.8428
p.P24L	TCGA-AU-3779	COAD	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	0.0833
p.P24L	DO8626	COAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.0833
p.A16V	TCGA-CD-A4MJ	STAD	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.A16V	TCGA-L5-A4OG	ESCA	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.A16V	DO47811	STAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.Q19E	TCGA-JW-A5VL	CESC	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	0.2222
p.Q19E	DO49976	CESC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2222
p.P15L	TCGA-RD-A8NB	STAD	TCGA	PRGRLAPIP	DEG_APCC_DBOX_1	0.6471
p.P15L	DO50142	STAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.6471
p.R18C	DO222892	BTCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.25
p.R18C	DO234154	ESAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.25
p.R14L	DO49886	CESC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.8428
p.V20F	DO10092	COAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.1944
p.N11D	DO222762	COCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.6932
p.V5I	DO222769	COCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2778
p.V20G	DO219910	DLBC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.1944
p.V20G	DO233213	GACA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.1944
p.R14S	DO234446	ESAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.7427
p.R22W	DO218693	GACA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.1389
p.T5A	DO233156	GACA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2778
p.A11S	DO15238	HNSC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.7588
p.G7R	DO231979	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.7568
p.C5F	DO228952	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2778
p.S24I	DO228974	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.0833
p.R10L	DO229028	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.7316
p.R10L	DO229038	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.7316
p.G5V	DO229034	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2778
p.A9S	DO229045	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.7588
p.S18Y	DO229047	LICA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.25
p.H16N	DO24596	LUAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.R18S	DO45328	LUAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.25
p.G19V	DO25010	LUAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2222
p.G19V	DO40884	UCEC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2222
p.G19V	DO41211	UCEC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2222
p.G6V	DO231152	LUSC	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.R18H	DO49178	PACA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.25
p.R22Q	DO35242	PACA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.1389
p.H16Y	DO51246	SKCM	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.A12V	DO47807	STAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.5825
p.Q17K	DO47925	STAD	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2778
p.L22R	DO229253	THCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.1389
p.G7V	DO229272	THCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.7532
p.S24C	DO229216	THCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.0833
p.A12T	DO229216	THCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.6028
p.Q17L	DO229232	THCA	ICGC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2778
p.Q2H	SIDM02021	Esophageal Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.1944
p.F21Y	SIDM00455	Pancreatic Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.1667
p.F21Y	ACH-000599	Pancreatic Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	0.1667
p.F21Y	PA-TU-8902	pancreas	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	0.1667
p.S23I	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.1111
p.N11S	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.7069
p.N11S	ACH-000693	Esophageal Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	0.7069
p.N11S	KYSE-180	oesophagus	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	0.7069
p.F3S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2222
p.F3S	ACH-002256	Leukemia	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	0.2222
p.G5C	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2778
p.H18Y	SIDM00151	Ovarian Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.25
p.H18Y	ACH-000966	Ovarian Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	0.25
p.H18Y	IGROV-1	ovary	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	0.25
p.M16V	SIDM00251	Gastric Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.M16V	ACH-000949	Gastric Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.M16V	TGBC11TKB	stomach	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.Q19H	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2222
p.Q19H	ACH-000544	Esophageal Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	0.2222
p.Q19H	OE21	oesophagus	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	0.2222
p.R8P	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.7512
p.R8P	ACH-002222	Leukemia	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	0.7512
p.H16D	SIDM00937	Oral Cavity Carcinoma	GDSC	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.H16D	ACH-000832	Head and Neck Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.H16D	CAL-27	upper_aerodigestive_tract	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	0.3056
p.P15Q	ACH-000826	Lung Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	0.5924
p.P15Q	CAL-12T	lung	COSMIC	PRGRLAPIP	DEG_APCC_DBOX_1	0.5924
p.Q10L	ACH-001345	Colon/Colorectal Cancer	CCLE	PRGRLAPIP	DEG_APCC_DBOX_1	0.7765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRGRLAPIP

Degron related mutations and impact score

Drug responses associated with RIMS2 mutations

All proteins holding degron of PRGRLAPIP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ26	Regulating synaptic membrane exocytosis protein 2	DEG_APCC_DBOX_1	7:15	PRGRLAPIP	APC,CDC20,FZR1	0.9236	More...