DegronMD

Uniprot ID: Q9UQ26

Source protein: Regulating synaptic membrane exocytosis protein 2

Source gene: RIMS2

Class: LIG_APCC_ABBA_1

Location: 384:389

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6597

ASA_SCORE: 100

COIL: 0.3737

CONS_SCORE: 0.4038

DSS_SCORE: 0.5666

HELIX: 0.5923

FCONS_SCORE: 0.9457

RIG_SCORE: 0.7399

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R387M	TCGA-17-Z028	LUAD	TCGA	MRIHAE	LIG_APCC_ABBA_1	0.8632
p.D380Y	TCGA-17-Z056	LUAD	TCGA	MRIHAE	LIG_APCC_ABBA_1	0.2222
p.D380Y	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	0.2222
p.D380Y	NCI-H2110	lung	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.2222
p.M388L	TCGA-37-4130	LUSC	TCGA	MRIHAE	LIG_APCC_ABBA_1	0.711
p.M388L	DO26490	LUSC	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.711
p.R387S	TCGA-69-7979	LUAD	TCGA	MRIHAE	LIG_APCC_ABBA_1	0.7427
p.R387S	DO23874	LUAD	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.7427
p.S392L	TCGA-75-5126	LUAD	TCGA	MRIHAE	LIG_APCC_ABBA_1	0.25
p.S392L	DO23711	LUAD	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.25
p.R395I	TCGA-BS-A0TC	UCEC	TCGA	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.R395I	DO42400	UCEC	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.R395I	SIDM01156	Small Cell Lung Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.R395I	SW1271	lung	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.R390G	TCGA-EA-A43B	CESC	TCGA	MRIHAE	LIG_APCC_ABBA_1	0.3056
p.R390G	DO44384	CESC	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.3056
p.N375H	TCGA-EO-A22R	UCEC	TCGA	MRIHAE	LIG_APCC_ABBA_1	0.0833
p.N375H	DO42713	UCEC	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.0833
p.D380N	DO1094	BRCA	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.2222
p.R382G	DO222884	COCA	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.Q375E	DO233223	GACA	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.0833
p.G383C	DO233222	GACA	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.3056
p.G383V	DO233652	GACA	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.3056
p.E388D	DO11651	GBM	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.6758
p.E388D	DO43202	UCEC	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.6758
p.E388D	SIDM01090	Colorectal Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	0.6758
p.E388D	ACH-000943	Colon/Colorectal Cancer	CCLE	MRIHAE	LIG_APCC_ABBA_1	0.6758
p.E388D	RKO	large_intestine	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.6758
p.G382D	DO52070	HNSC	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.W392C	DO228976	LICA	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.25
p.R382M	DO229036	LICA	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.M378K	DO231602	LINC	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.E377Q	DO48751	LIRI	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.1389
p.Q396L	DO45346	LUAD	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.1389
p.E379K	DO222396	MELA	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.1944
p.E387Q	DO29258	OV	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.6744
p.S393Y	DO36881	READ	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.2222
p.S398L	DO218880	SKCA	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.0833
p.E377K	DO37831	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.1389
p.E377K	DO51254	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.1389
p.E377K	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.1389
p.G382S	DO37996	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.K398N	DO37971	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.0833
p.P395S	DO47359	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.P395L	DO47359	SKCM	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.G382V	DO38479	STAD	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.Q396R	DO38679	STAD	ICGC	MRIHAE	LIG_APCC_ABBA_1	0.1389
p.M378R	SIDM00845	Burkitt's Lymphoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.M378R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.F381Y	SIDM00845	Burkitt's Lymphoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	0.25
p.F381Y	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.25
p.R382S	SIDM00064	Hepatocellular Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.R382S	SIDM00587	Biliary Tract Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.R382S	SIDM00280	Gastric Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.R382S	HuCCT1	biliary_tract	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.R382S	ECC10	stomach	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.R382S	HLE	liver	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.2778
p.P395T	SIDM00812	Colorectal Carcinoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.P395T	ACH-000236	Colon/Colorectal Cancer	CCLE	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.P395T	SW1417	large_intestine	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.R393K	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	MRIHAE	LIG_APCC_ABBA_1	0.2222
p.R393K	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.2222
p.M378V	ACH-000209	Bile Duct Cancer	CCLE	MRIHAE	LIG_APCC_ABBA_1	0.1667
p.M388I	ACH-000395	Lung Cancer	CCLE	MRIHAE	LIG_APCC_ABBA_1	0.7618
p.M388I	NCI-H520	lung	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.7618
p.G392D	ACH-000853	Lung Cancer	CCLE	MRIHAE	LIG_APCC_ABBA_1	0.25
p.G392D	NCI-H661	lung	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.25
p.A377P	ACH-002358	Non-Cancerous	CCLE	MRIHAE	LIG_APCC_ABBA_1	0.1389
p.V375L	NCI-H650	lung	COSMIC	MRIHAE	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MRIHAE

Degron related mutations and impact score

Drug responses associated with RIMS2 mutations

All proteins holding degron of MRIHAE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ26	Regulating synaptic membrane exocytosis protein 2	LIG_APCC_ABBA_1	384:389	MRIHAE	APC,CDC20,FZR1	0.6597	More...