DegronMD

Uniprot ID: Q92870

Source protein: Amyloid beta precursor protein binding family B member 2

Source gene: APBB2

Class: DEG_SCF_FBW7_2

Location: 340:347

E3 ligase: FBXW7

DEGRON score: 0.6569

ASA_SCORE: 93.225

COIL: 0.8796

CONS_SCORE: 0.4734

DSS_SCORE: 0.6637

HELIX: 0.0946

FCONS_SCORE: 1.2215

RIG_SCORE: 0.6004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T340M	TCGA-AA-3811	COAD	TCGA	PSPTPENE	DEG_SCF_FBW7_2	0.7423
p.T340M	DO7962	COAD	ICGC	PSPTPENE	DEG_SCF_FBW7_2	0.7423
p.P345T	TCGA-D3-A2J6	SKCM	TCGA	PSPTPENE	DEG_SCF_FBW7_2	0.7031
p.P345T	DO37901	SKCM	ICGC	PSPTPENE	DEG_SCF_FBW7_2	0.7031
p.S342F	TCGA-D3-A8GB	SKCM	TCGA	PSPTPENE	DEG_SCF_FBW7_2	0.7982
p.S342F	DO50280	SKCM	ICGC	PSPTPENE	DEG_SCF_FBW7_2	0.7982
p.S335P	TCGA-D7-A4YY	STAD	TCGA	PSPTPENE	DEG_SCF_FBW7_2	0.1944
p.S335P	DO47733	STAD	ICGC	PSPTPENE	DEG_SCF_FBW7_2	0.1944
p.S335L	TCGA-FW-A3R5	SKCM	TCGA	PSPTPENE	DEG_SCF_FBW7_2	0.1944
p.P343L	TCGA-IH-A3EA	SKCM	TCGA	PSPTPENE	DEG_SCF_FBW7_2	0.7582
p.P343L	DO37667	SKCM	ICGC	PSPTPENE	DEG_SCF_FBW7_2	0.7582
p.S334L	DO37406	SKCM	ICGC	PSPTPENE	DEG_SCF_FBW7_2	0.6111
p.R332S	SIDM01129	Small Cell Lung Carcinoma	GDSC	PSPTPENE	DEG_SCF_FBW7_2	0.5556
p.R332S	NCI-H524	lung	COSMIC	PSPTPENE	DEG_SCF_FBW7_2	0.5556
p.D357E	ASH-3	thyroid	COSMIC	PSPTPENE	DEG_SCF_FBW7_2	0.0556
p.R331S	NCI-H524	lung	COSMIC	PSPTPENE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92870	Amyloid beta precursor protein binding family B member 2	DEG_SCF_FBW7_2	340:347	PSPTPENE	FBXW7	0.6569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons