DegronMD

Uniprot ID: Q92870

Source protein: Amyloid beta precursor protein binding family B member 2

Source gene: APBB2

Class: DEG_SCF_FBW7_1

Location: 32:38

E3 ligase: FBXW7

DEGRON score: 0.9854

ASA_SCORE: 83.5143

COIL: 0.9294

CONS_SCORE: 0.4149

DSS_SCORE: 0.687

HELIX: 0.0409

FCONS_SCORE: 0.9836

RIG_SCORE: 0.6516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N28D	TCGA-A5-A0G2	UCEC	TCGA	PATPPNT	DEG_SCF_FBW7_1	0.2222
p.N28D	DO41235	UCEC	ICGC	PATPPNT	DEG_SCF_FBW7_1	0.2222
p.P36S	TCGA-EB-A4XL	SKCM	TCGA	PATPPNT	DEG_SCF_FBW7_1	0.5641
p.P36S	DO47401	SKCM	ICGC	PATPPNT	DEG_SCF_FBW7_1	0.5641
p.P36T	TCGA-FU-A23L	CESC	TCGA	PATPPNT	DEG_SCF_FBW7_1	0.5919
p.P36T	DO6278	CESC	ICGC	PATPPNT	DEG_SCF_FBW7_1	0.5919
p.V44L	DO228934	LICA	ICGC	PATPPNT	DEG_SCF_FBW7_1	0.1667
p.L48M	DO229041	LICA	ICGC	PATPPNT	DEG_SCF_FBW7_1	0.0556
p.G48A	DO50301	SKCM	ICGC	PATPPNT	DEG_SCF_FBW7_1	0.0556
p.L23F	DO51286	SKCM	ICGC	PATPPNT	DEG_SCF_FBW7_1	0.0833
p.V44M	DO38743	STAD	ICGC	PATPPNT	DEG_SCF_FBW7_1	0.1667
p.N30S	SIDM01580	Melanoma	GDSC	PATPPNT	DEG_SCF_FBW7_1	0.2778
p.N30S	ACH-000240	Non-Cancerous	CCLE	PATPPNT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92870	Amyloid beta precursor protein binding family B member 2	DEG_SCF_FBW7_1	32:38	PATPPNT	FBXW7	0.9854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons