DegronMD

Uniprot ID: Q92870

Source protein: Amyloid beta precursor protein binding family B member 2

Source gene: APBB2

Class: DEG_SCF_FBW7_2

Location: 580:585

E3 ligase: FBXW7

DEGRON score: 0.9612

ASA_SCORE: 82.0833

COIL: 0.7693

CONS_SCORE: 0.7831

DSS_SCORE: 0.1921

HELIX: 0.152

FCONS_SCORE: 1.3026

RIG_SCORE: 0.7912

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E586K	TCGA-73-4658	LUAD	TCGA	PTPKTE	DEG_SCF_FBW7_2	0.3056
p.P581L	TCGA-A5-A0GH	UCEC	TCGA	PTPKTE	DEG_SCF_FBW7_2	0.7582
p.V593M	TCGA-BR-4256	STAD	TCGA	PTPKTE	DEG_SCF_FBW7_2	0.1111
p.L572F	TCGA-WE-A8ZO	SKCM	TCGA	PTPKTE	DEG_SCF_FBW7_2	0.1111
p.P582L	DO234268	ESAD	ICGC	PTPKTE	DEG_SCF_FBW7_2	0.7582
p.Q594R	SIDM01439	Hepatocellular Carcinoma	GDSC	PTPKTE	DEG_SCF_FBW7_2	0.0833
p.Q594R	SIDM01378	Ovarian Carcinoma	GDSC	PTPKTE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92870	Amyloid beta precursor protein binding family B member 2	DEG_SCF_FBW7_2	580:585	PTPKTE	FBXW7	0.9612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons