DegronMD

Uniprot ID: Q92870

Source protein: Amyloid beta precursor protein binding family B member 2

Source gene: APBB2

Class: DEG_APCC_DBOX_1

Location: 738:746

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9181

ASA_SCORE: 56.9667

COIL: 0.0517

CONS_SCORE: 0.522

DSS_SCORE: 0.4786

HELIX: 0.9454

FCONS_SCORE: 1.1408

RIG_SCORE: 0.8109

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P754L	TCGA-AD-6964	COAD	TCGA	KRGVLSLID	DEG_APCC_DBOX_1	0.1111
p.R753C	TCGA-AP-A059	UCEC	TCGA	KRGVLSLID	DEG_APCC_DBOX_1	0.1389
p.P732L	DO8360	COAD	ICGC	KRGVLSLID	DEG_APCC_DBOX_1	0.1667
p.P737S	DO40884	UCEC	ICGC	KRGVLSLID	DEG_APCC_DBOX_1	0.3056
p.Q751H	SIDM00664	Pancreatic Carcinoma	GDSC	KRGVLSLID	DEG_APCC_DBOX_1	0.3056
p.Q751H	ACH-000178	Pancreatic Cancer	CCLE	KRGVLSLID	DEG_APCC_DBOX_1	0.3056
p.Q751H	Hs766T	pancreas	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	0.3056
p.S744F	SIDM00140	Melanoma	GDSC	KRGVLSLID	DEG_APCC_DBOX_1	0.7982
p.S744F	ACH-000968	Skin Cancer	CCLE	KRGVLSLID	DEG_APCC_DBOX_1	0.7982
p.S744F	COLO-792	skin	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	0.7982
p.N737K	ACH-001282	Bone Cancer	CCLE	KRGVLSLID	DEG_APCC_DBOX_1	0.3056
p.Q750H	Hs766T	pancreas	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	0.2222
p.S743F	COLO-792	skin	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	0.7982
p.Q728H	Hs766T	pancreas	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	0.0556
p.Q729H	Hs766T	pancreas	COSMIC	KRGVLSLID	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92870	Amyloid beta precursor protein binding family B member 2	DEG_APCC_DBOX_1	738:746	KRGVLSLID	APC,CDC20,FZR1	0.9181	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons