DegronMD

Uniprot ID: Q9BZB8

Source protein: Cytoplasmic polyadenylation element-binding protein 1

Source gene: CPEB1

Class: DEG_SIAH_1

Location: 254:262

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9725

ASA_SCORE: 52.0889

COIL: 0.8621

CONS_SCORE: 0.3051

DSS_SCORE: 0.406

HELIX: 0.0949

FCONS_SCORE: 0.9047

RIG_SCORE: 0.7163

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P272H	TCGA-55-7913	LUAD	TCGA	WPGASVWPS	DEG_SIAH_1	0.0556
p.S258F	TCGA-AX-A2HC	UCEC	TCGA	WPGASVWPS	DEG_SIAH_1	0.6871
p.S249R	TCGA-C8-A138	BRCA	TCGA	WPGASVWPS	DEG_SIAH_1	0.1944
p.A250T	TCGA-EO-A22R	UCEC	TCGA	WPGASVWPS	DEG_SIAH_1	0.2222
p.R253T	TCGA-IR-A3LK	CESC	TCGA	WPGASVWPS	DEG_SIAH_1	0.3056
p.V253G	DO1285	BRCA	ICGC	WPGASVWPS	DEG_SIAH_1	0.3056
p.F259V	DO8842	COAD	ICGC	WPGASVWPS	DEG_SIAH_1	0.7068
p.G260S	DO23292	LINC	ICGC	WPGASVWPS	DEG_SIAH_1	0.6993
p.G271S	DO47331	SKCM	ICGC	WPGASVWPS	DEG_SIAH_1	0.0833
p.G256E	SIDM00504	Glioma	GDSC	WPGASVWPS	DEG_SIAH_1	0.6087
p.G256E	MOG-G-UVW	central_nervous_system	COSMIC	WPGASVWPS	DEG_SIAH_1	0.6087
p.G255R	ACH-000196	Breast Cancer	CCLE	WPGASVWPS	DEG_SIAH_1	0.7568
p.G255R	HCC1599	breast	COSMIC	WPGASVWPS	DEG_SIAH_1	0.7568
p.A269V	ACH-000973	Bladder Cancer	CCLE	WPGASVWPS	DEG_SIAH_1	0.1389
p.A269V	639-V	urinary_tract	COSMIC	WPGASVWPS	DEG_SIAH_1	0.1389
p.G259E	MOG-G-UVW	central_nervous_system	COSMIC	WPGASVWPS	DEG_SIAH_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1	DEG_SIAH_1	254:262	WPGASVWPS	SIAH1,SIAH2,SIAH3	0.9725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons