DegronMD

Uniprot ID: Q9BZB8

Source protein: Cytoplasmic polyadenylation element-binding protein 1

Source gene: CPEB1

Class: DEG_SPOP_SBC_1

Location: 120:124

E3 ligase: SPOP

DEGRON score: 0.6813

ASA_SCORE: 68.58

COIL: 0.8032

CONS_SCORE: 0.3092

DSS_SCORE: 0.4929

HELIX: 0.161

FCONS_SCORE: 0.9612

RIG_SCORE: 0.5997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P110H	TCGA-23-1123	OV	TCGA	AQSST	DEG_SPOP_SBC_1	0.0556
p.A120D	TCGA-37-4130	LUSC	TCGA	AQSST	DEG_SPOP_SBC_1	0.7793
p.L131F	TCGA-AN-A046	BRCA	TCGA	AQSST	DEG_SPOP_SBC_1	0.1389
p.W111C	TCGA-AR-A0U4	BRCA	TCGA	AQSST	DEG_SPOP_SBC_1	0.0833
p.R131C	DO222798	COCA	ICGC	AQSST	DEG_SPOP_SBC_1	0.1389
p.D121Y	DO23678	LUAD	ICGC	AQSST	DEG_SPOP_SBC_1	0.7325
p.D121H	DO23602	LUAD	ICGC	AQSST	DEG_SPOP_SBC_1	0.7688
p.S122R	SIDM00081	Melanoma	GDSC	AQSST	DEG_SPOP_SBC_1	0.7427
p.S122R	SIDM01567	Hodgkin's Lymphoma	GDSC	AQSST	DEG_SPOP_SBC_1	0.7427
p.D121G	ACH-000786	Lymphoma	CCLE	AQSST	DEG_SPOP_SBC_1	0.7198
p.D121G	ACH-000992	Head and Neck Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.7198
p.D121G	ACH-001067	Brain Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.7198
p.D121G	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	0.7198
p.D121G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	0.7198
p.S113P	ACH-000786	Lymphoma	CCLE	AQSST	DEG_SPOP_SBC_1	0.1389
p.S113P	ACH-000992	Head and Neck Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.1389
p.S113P	ACH-001067	Brain Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.1389
p.S113P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	0.1389
p.G133S	ACH-000823	Esophageal Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.0833
p.G133S	KYSE-140	oesophagus	COSMIC	AQSST	DEG_SPOP_SBC_1	0.0833
p.D110G	COR-L95	lung	COSMIC	AQSST	DEG_SPOP_SBC_1	0.0556
p.T133I	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	0.0833
p.I114T	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	0.1667
p.H119N	HT-115	large_intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	559:563	AQSST	SPOP	0.9964	More...
O95886	Disks large-associated protein 3	DEG_SPOP_SBC_1	558:562	AQSST	SPOP	0.9926	More...
Q7Z6J0	E3 ubiquitin-protein ligase SH3RF1	DEG_SPOP_SBC_1	284:288	AQSST	SPOP	0.9813	More...
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1	DEG_SPOP_SBC_1	120:124	AQSST	SPOP	0.6813	More...
Q9NZN9	Aryl-hydrocarbon-interacting protein-like 1	DEG_SPOP_SBC_1	344:348	AQSST	SPOP	0.929	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	630:634	AQSST	SPOP	0.992	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	130:134	AQSST	SPOP	0.8302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AQSST

Degron related mutations and impact score

Drug responses associated with CPEB1 mutations

All proteins holding degron of AQSST