DegronMD - Q7Z6J0(SH3RF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A595V	TCGA-19-5956	GBM	TCGA	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation rewiring degron network	0.1944
p.A595V	TCGA-IB-7651	PAAD	TCGA	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation rewiring degron network	0.1944
p.A595V	DO13863	GBM	ICGC	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation rewiring degron network	0.1944
p.A595V	DO46657	PAAD	ICGC	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation rewiring degron network	0.1944
p.A595V	DO229257	THCA	ICGC	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation rewiring degron network	0.1944
p.I359T	TCGA-90-A4ED	LUSC	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1944
p.I359T	DO45482	LUSC	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1944
p.A614T	TCGA-AP-A1DV	UCEC	TCGA	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation rewiring degron network	0.1667
p.A614T	DO43186	UCEC	ICGC	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation rewiring degron network	0.1667
p.G363W	TCGA-D3-A1Q3	SKCM	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.3056
p.G363W	TCGA-D3-A2JN	SKCM	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.3056
p.G363W	TCGA-GF-A2C7	SKCM	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.3056
p.G363W	DO37407	SKCM	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.3056
p.G363W	DO47590	SKCM	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.3056
p.G363W	DO47509	SKCM	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.3056
p.G377S	TCGA-D8-A73U	BRCA	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1667
p.G377S	DO219629	BRCA	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1667
p.P368S	TCGA-DA-A1HY	SKCM	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation altering degron motif	0.6752
p.P368S	DO37409	SKCM	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation altering degron motif	0.6752
p.S379L	TCGA-F5-6814	READ	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1111
p.S379L	DO233652	GACA	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1111
p.S379L	DO36556	READ	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1111
p.R600H	TCGA-VS-A9U6	CESC	TCGA	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation altering degron motif	0.7133
p.R600H	DO219728	CESC	ICGC	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation altering degron motif	0.7133
p.Q609K	DO228952	LICA	ICGC	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation rewiring degron network	0.3056
p.A289D	DO229006	LICA	ICGC	AQSST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.3056
p.Q285K	DO229006	LICA	ICGC	AQSST	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.5833
p.D294N	DO232761	PBCA	ICGC	AQSST	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.V357A	DO229453	SKCA	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation rewiring degron network	0.1389
p.T602M	DO229259	THCA	ICGC	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation altering degron motif	0.6312
p.T602M	SIDM00596	Endometrial Carcinoma	GDSC	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation altering degron motif	0.6312
p.T602M	ACH-000954	Endometrial/Uterine Cancer	CCLE	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation altering degron motif	0.6312
p.T602M	ACH-001517	Endometrial/Uterine Cancer	CCLE	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation altering degron motif	0.6312
p.T602M	HEC-1	endometrium	COSMIC	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation altering degron motif	0.6312
p.R600L	DO229227	THCA	ICGC	RPTAAVTPI	DEG_SIAH_1	600:608	Mutation altering degron motif	0.7316
p.P369H	ACH-001131	Skin Cancer	CCLE	LIVTPPPS	DEG_SCF_FBW7_1	364:371	Mutation altering degron motif	0.6583

Kaplan plot for SH3RF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3RF1

UniProt ID: Q7Z6J0

Entrez ID: 57630

Protein name: E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH3RF1 in