DegronMD

Uniprot ID: Q7Z6J0

Source protein: E3 ubiquitin-protein ligase SH3RF1

Source gene: SH3RF1

Class: DEG_SIAH_1

Location: 600:608

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9956

ASA_SCORE: 67.6111

COIL: 0.8352

CONS_SCORE: 0.4646

DSS_SCORE: 0.5282

HELIX: 0.1257

FCONS_SCORE: 1.1763

RIG_SCORE: 0.7671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A595V	TCGA-19-5956	GBM	TCGA	RPTAAVTPI	DEG_SIAH_1	0.1944
p.A595V	TCGA-IB-7651	PAAD	TCGA	RPTAAVTPI	DEG_SIAH_1	0.1944
p.A595V	DO13863	GBM	ICGC	RPTAAVTPI	DEG_SIAH_1	0.1944
p.A595V	DO46657	PAAD	ICGC	RPTAAVTPI	DEG_SIAH_1	0.1944
p.A595V	DO229257	THCA	ICGC	RPTAAVTPI	DEG_SIAH_1	0.1944
p.A614T	TCGA-AP-A1DV	UCEC	TCGA	RPTAAVTPI	DEG_SIAH_1	0.1667
p.A614T	DO43186	UCEC	ICGC	RPTAAVTPI	DEG_SIAH_1	0.1667
p.R600H	TCGA-VS-A9U6	CESC	TCGA	RPTAAVTPI	DEG_SIAH_1	0.7133
p.R600H	DO219728	CESC	ICGC	RPTAAVTPI	DEG_SIAH_1	0.7133
p.Q609K	DO228952	LICA	ICGC	RPTAAVTPI	DEG_SIAH_1	0.3056
p.T602M	DO229259	THCA	ICGC	RPTAAVTPI	DEG_SIAH_1	0.6312
p.T602M	SIDM00596	Endometrial Carcinoma	GDSC	RPTAAVTPI	DEG_SIAH_1	0.6312
p.T602M	ACH-000954	Endometrial/Uterine Cancer	CCLE	RPTAAVTPI	DEG_SIAH_1	0.6312
p.T602M	ACH-001517	Endometrial/Uterine Cancer	CCLE	RPTAAVTPI	DEG_SIAH_1	0.6312
p.T602M	HEC-1	endometrium	COSMIC	RPTAAVTPI	DEG_SIAH_1	0.6312
p.R600L	DO229227	THCA	ICGC	RPTAAVTPI	DEG_SIAH_1	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6J0	E3 ubiquitin-protein ligase SH3RF1	DEG_SIAH_1	600:608	RPTAAVTPI	SIAH1,SIAH2,SIAH3	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons