DegronMD

Uniprot ID: Q7Z6J0

Source protein: E3 ubiquitin-protein ligase SH3RF1

Source gene: SH3RF1

Class: DEG_SCF_FBW7_1

Location: 364:371

E3 ligase: FBXW7

DEGRON score: 0.9825

ASA_SCORE: 86.8625

COIL: 0.9614

CONS_SCORE: 0.4166

DSS_SCORE: 0.5122

HELIX: 0.0118

FCONS_SCORE: 1.0698

RIG_SCORE: 0.6744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I359T	TCGA-90-A4ED	LUSC	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	0.1944
p.I359T	DO45482	LUSC	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	0.1944
p.G363W	TCGA-D3-A1Q3	SKCM	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	0.3056
p.G363W	TCGA-D3-A2JN	SKCM	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	0.3056
p.G363W	TCGA-GF-A2C7	SKCM	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	0.3056
p.G363W	DO37407	SKCM	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	0.3056
p.G363W	DO47590	SKCM	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	0.3056
p.G363W	DO47509	SKCM	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	0.3056
p.G377S	TCGA-D8-A73U	BRCA	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	0.1667
p.G377S	DO219629	BRCA	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	0.1667
p.P368S	TCGA-DA-A1HY	SKCM	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	0.6752
p.P368S	DO37409	SKCM	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	0.6752
p.S379L	TCGA-F5-6814	READ	TCGA	LIVTPPPS	DEG_SCF_FBW7_1	0.1111
p.S379L	DO233652	GACA	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	0.1111
p.S379L	DO36556	READ	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	0.1111
p.V357A	DO229453	SKCA	ICGC	LIVTPPPS	DEG_SCF_FBW7_1	0.1389
p.P369H	ACH-001131	Skin Cancer	CCLE	LIVTPPPS	DEG_SCF_FBW7_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6J0	E3 ubiquitin-protein ligase SH3RF1	DEG_SCF_FBW7_1	364:371	LIVTPPPS	FBXW7	0.9825	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons