DegronMD

Uniprot ID: Q9P1A6

Source protein: Disks large-associated protein 2

Source gene: DLGAP2

Class: DEG_SPOP_SBC_1

Location: 630:634

E3 ligase: SPOP

DEGRON score: 0.992

ASA_SCORE: 80.94

COIL: 0.8774

CONS_SCORE: 0.5109

DSS_SCORE: 0.6215

HELIX: 0.0876

FCONS_SCORE: 1.0559

RIG_SCORE: 0.6441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q640R	TCGA-3C-AALI	BRCA	TCGA	AQSST	DEG_SPOP_SBC_1	0.1667
p.Q640R	DO219589	BRCA	ICGC	AQSST	DEG_SPOP_SBC_1	0.1667
p.S635P	TCGA-DF-A2KU	UCEC	TCGA	AQSST	DEG_SPOP_SBC_1	0.3056
p.S635P	DO223286	UCEC	ICGC	AQSST	DEG_SPOP_SBC_1	0.3056
p.F644L	TCGA-EO-A22X	UCEC	TCGA	AQSST	DEG_SPOP_SBC_1	0.0556
p.F644L	DO43907	UCEC	ICGC	AQSST	DEG_SPOP_SBC_1	0.0556
p.A626V	TCGA-VQ-A8P2	STAD	TCGA	AQSST	DEG_SPOP_SBC_1	0.2222
p.A626V	DO234446	ESAD	ICGC	AQSST	DEG_SPOP_SBC_1	0.2222
p.A626V	DO233106	GACA	ICGC	AQSST	DEG_SPOP_SBC_1	0.2222
p.A626V	DO51761	STAD	ICGC	AQSST	DEG_SPOP_SBC_1	0.2222
p.D641N	DO222701	ESCA	ICGC	AQSST	DEG_SPOP_SBC_1	0.1389
p.A626T	DO27813	MALY	ICGC	AQSST	DEG_SPOP_SBC_1	0.2222
p.V629M	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	AQSST	DEG_SPOP_SBC_1	0.3056
p.V629M	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	0.3056
p.A641T	SIDM00220	Ovarian Carcinoma	GDSC	AQSST	DEG_SPOP_SBC_1	0.1389
p.A641T	OC-314	ovary	COSMIC	AQSST	DEG_SPOP_SBC_1	0.1389
p.S635F	ACH-001002	Skin Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	0.3056
p.S635F	451Lu	skin	COSMIC	AQSST	DEG_SPOP_SBC_1	0.3056
p.A640T	OC-314	ovary	COSMIC	AQSST	DEG_SPOP_SBC_1	0.1667
p.V628M	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	559:563	AQSST	SPOP	0.9964	More...
O95886	Disks large-associated protein 3	DEG_SPOP_SBC_1	558:562	AQSST	SPOP	0.9926	More...
Q7Z6J0	E3 ubiquitin-protein ligase SH3RF1	DEG_SPOP_SBC_1	284:288	AQSST	SPOP	0.9813	More...
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1	DEG_SPOP_SBC_1	120:124	AQSST	SPOP	0.6813	More...
Q9NZN9	Aryl-hydrocarbon-interacting protein-like 1	DEG_SPOP_SBC_1	344:348	AQSST	SPOP	0.929	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	630:634	AQSST	SPOP	0.992	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	130:134	AQSST	SPOP	0.8302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons