DegronMD

Uniprot ID: O14490

Source protein: Disks large-associated protein 1

Source gene: DLGAP1

Class: DEG_SPOP_SBC_1

Location: 559:563

E3 ligase: SPOP

DEGRON score: 0.9964

ASA_SCORE: 76.56

COIL: 0.8142

CONS_SCORE: 0.4775

DSS_SCORE: 0.5465

HELIX: 0.0922

FCONS_SCORE: 1.1591

RIG_SCORE: 0.7074

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y570N	TCGA-73-A9RS	LUAD	TCGA	AQSST	DEG_SPOP_SBC_1	0.1389
p.Q567H	TCGA-D8-A1JK	BRCA	TCGA	AQSST	DEG_SPOP_SBC_1	0.2222
p.P573H	DO8018	COAD	ICGC	AQSST	DEG_SPOP_SBC_1	0.0556
p.P567R	DO25967	LUAD	ICGC	AQSST	DEG_SPOP_SBC_1	0.2222
p.H570Y	DO26469	LUSC	ICGC	AQSST	DEG_SPOP_SBC_1	0.1389
p.R558K	DO48899	PBCA	ICGC	AQSST	DEG_SPOP_SBC_1	0.3056
p.C561G	DO47436	SKCM	ICGC	AQSST	DEG_SPOP_SBC_1	0.76
p.K553I	DO41536	UCEC	ICGC	AQSST	DEG_SPOP_SBC_1	0.1667
p.N562S	NCI-H1048	lung	COSMIC	AQSST	DEG_SPOP_SBC_1	0.7069
p.D573E	DU-145	prostate	COSMIC	AQSST	DEG_SPOP_SBC_1	0.0556
p.D565E	DU-145	prostate	COSMIC	AQSST	DEG_SPOP_SBC_1	0.2778
p.G570R	NCI-H630	large_intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	0.1389
p.N554S	NCI-H1048	lung	COSMIC	AQSST	DEG_SPOP_SBC_1	0.1944
p.G562R	NCI-H630	large_intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	0.7568
p.T555I	CW-2	large_intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	0.2222
p.G556R	NCI-H630	large_intestine	COSMIC	AQSST	DEG_SPOP_SBC_1	0.25
p.N564S	NCI-H1048	lung	COSMIC	AQSST	DEG_SPOP_SBC_1	0.3056
p.D559E	DU-145	prostate	COSMIC	AQSST	DEG_SPOP_SBC_1	0.6758
p.N572S	NCI-H1048	lung	COSMIC	AQSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	559:563	AQSST	SPOP	0.9964	More...
O95886	Disks large-associated protein 3	DEG_SPOP_SBC_1	558:562	AQSST	SPOP	0.9926	More...
Q7Z6J0	E3 ubiquitin-protein ligase SH3RF1	DEG_SPOP_SBC_1	284:288	AQSST	SPOP	0.9813	More...
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1	DEG_SPOP_SBC_1	120:124	AQSST	SPOP	0.6813	More...
Q9NZN9	Aryl-hydrocarbon-interacting protein-like 1	DEG_SPOP_SBC_1	344:348	AQSST	SPOP	0.929	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	630:634	AQSST	SPOP	0.992	More...
Q5JRM2	Uncharacterized protein CXorf66	DEG_SPOP_SBC_1	130:134	AQSST	SPOP	0.8302	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons