DegronMD

Uniprot ID: Q2KJY2

Source protein: Kinesin-like protein KIF26B

Source gene: KIF26B

Class: DEG_SCF_TRCP1_1

Location: 1110:1115

E3 ligase: BTRC

DEGRON score: 0.9774

ASA_SCORE: 70.5667

COIL: 0.8237

CONS_SCORE: 0.3354

DSS_SCORE: 0.6707

HELIX: 0.113

FCONS_SCORE: 1.0206

RIG_SCORE: 0.6034

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1123V	TCGA-49-AARN	LUAD	TCGA	DSGVAS	DEG_SCF_TRCP1_1	0.1111
p.A1114V	TCGA-AA-3949	COAD	TCGA	DSGVAS	DEG_SCF_TRCP1_1	0.5825
p.A1114V	TCGA-AA-3977	COAD	TCGA	DSGVAS	DEG_SCF_TRCP1_1	0.5825
p.A1114V	SIDM00265	Ewing's Sarcoma	GDSC	DSGVAS	DEG_SCF_TRCP1_1	0.5825
p.A1114V	ACH-002104	Bone Cancer	CCLE	DSGVAS	DEG_SCF_TRCP1_1	0.5825
p.A1114V	ES3	bone	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	0.5825
p.R1125H	TCGA-AX-A2HC	UCEC	TCGA	DSGVAS	DEG_SCF_TRCP1_1	0.0556
p.V1113M	TCGA-BH-A18M	BRCA	TCGA	DSGVAS	DEG_SCF_TRCP1_1	0.6097
p.V1113M	TCGA-KB-A93H	STAD	TCGA	DSGVAS	DEG_SCF_TRCP1_1	0.6097
p.R1125C	TCGA-BM-6198	READ	TCGA	DSGVAS	DEG_SCF_TRCP1_1	0.0556
p.G1112V	TCGA-CV-6935	HNSC	TCGA	DSGVAS	DEG_SCF_TRCP1_1	0.7532
p.E1123K	TCGA-D3-A2JE	SKCM	TCGA	DSGVAS	DEG_SCF_TRCP1_1	0.1111
p.E1117K	TCGA-MI-A75E	LIHC	TCGA	DSGVAS	DEG_SCF_TRCP1_1	0.2778
p.D1123V	DO51024	LAML	ICGC	DSGVAS	DEG_SCF_TRCP1_1	0.1111
p.G1114A	DO45540	LUSC	ICGC	DSGVAS	DEG_SCF_TRCP1_1	0.754
p.P1105Q	DO46657	PAAD	ICGC	DSGVAS	DEG_SCF_TRCP1_1	0.1944
p.S1112I	DO39505	THCA	ICGC	DSGVAS	DEG_SCF_TRCP1_1	0.7341
p.Q1121H	SIDM00535	Chondrosarcoma	GDSC	DSGVAS	DEG_SCF_TRCP1_1	0.1667
p.Q1121H	ACH-001519	Bone Cancer	CCLE	DSGVAS	DEG_SCF_TRCP1_1	0.1667
p.Q1121H	H-EMC-SS	bone	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	0.1667
p.L1120M	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	DSGVAS	DEG_SCF_TRCP1_1	0.1944
p.L1120M	ACH-000893	Lung Cancer	CCLE	DSGVAS	DEG_SCF_TRCP1_1	0.1944
p.L1120M	NCI-H1651	lung	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	0.1944
p.P1106S	SIDM00006	Other Solid Cancers	GDSC	DSGVAS	DEG_SCF_TRCP1_1	0.2222
p.P1106S	ACH-001552	Skin Cancer	CCLE	DSGVAS	DEG_SCF_TRCP1_1	0.2222
p.P1106S	MCC26	skin	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	0.2222
p.A1102T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGVAS	DEG_SCF_TRCP1_1	0.1111
p.A1102S	SIDM01574	Plasma Cell Myeloma	GDSC	DSGVAS	DEG_SCF_TRCP1_1	0.1111
p.A1102S	ACH-000588	Myeloma	CCLE	DSGVAS	DEG_SCF_TRCP1_1	0.1111
p.S1117L	BT-474	breast	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	0.2778
p.P1103H	SW620	large_intestine	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	0.1389
p.L1109F	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVAS	DEG_SCF_TRCP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGVAS

Degron related mutations and impact score

Drug responses associated with KIF26B mutations

All proteins holding degron of DSGVAS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KJY2	Kinesin-like protein KIF26B	DEG_SCF_TRCP1_1	1110:1115	DSGVAS	BTRC	0.9774	More...