DegronMD - O94972(TRIM37)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R599T	TCGA-18-3406	LUSC	TCGA	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.S587C	TCGA-AD-6895	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.S587C	DO8938	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.T601A	TCGA-AX-A06H	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1667
p.T601A	DO43530	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1667
p.S587N	TCGA-B5-A0JY	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.S587N	SIDM00789	Colorectal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.S587N	ACH-000997	Colon/Colorectal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.S587N	ACH-001061	Colon/Colorectal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.S587N	ACH-001091	Colon/Colorectal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.S587N	HCT-15	large intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.2222
p.T262A	TCGA-BS-A0UV	UCEC	TCGA	DFTSELVPSY	DEG_COP1_1	267:276	Mutation blocking phosphorylation signal	0.6389
p.P263S	TCGA-C4-A0F1	BLCA	TCGA	DFTSELVPSY	DEG_COP1_1	267:276	Mutation rewiring degron network	0.2222
p.E284D	TCGA-CA-6717	COAD	TCGA	DFTSELVPSY	DEG_COP1_1	267:276	Mutation rewiring degron network	0.1111
p.D267N	TCGA-CA-6717	COAD	TCGA	DFTSELVPSY	DEG_COP1_1	267:276	Mutation altering degron motif	0.6932
p.A584S	TCGA-CX-7219	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1389
p.V327L	TCGA-DD-A3A8	LIHC	TCGA	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation altering degron motif	0.5654
p.S332L	TCGA-E5-A4TZ	BLCA	TCGA	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2778
p.S593F	TCGA-FR-A729	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation altering degron motif	0.7982
p.F286L	TCGA-FS-A1ZP	SKCM	TCGA	DFTSELVPSY	DEG_COP1_1	267:276	Mutation rewiring degron network	0.0556
p.P274S	TCGA-MX-A5UJ	STAD	TCGA	DFTSELVPSY	DEG_COP1_1	267:276	Mutation altering degron motif	0.6752
p.G271V	DO51915	BLCA	ICGC	DFTSELVPSY	DEG_COP1_1	267:276	Mutation altering degron motif	0.7532
p.G271V	DO223723	LUSC	ICGC	DFTSELVPSY	DEG_COP1_1	267:276	Mutation altering degron motif	0.7532
p.Q268E	DO2919	BRCA	ICGC	DFTSELVPSY	DEG_COP1_1	267:276	Mutation altering degron motif	0.6744
p.P261T	DO6290	CESC	ICGC	DFTSELVPSY	DEG_COP1_1	267:276	Mutation blocking phosphorylation signal	0.6111
p.A584V	DO227646	COCA	ICGC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1389
p.K323E	DO233647	GACA	ICGC	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2778
p.P605H	DO229019	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.0556
p.P583T	DO229032	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1111
p.N324K	DO47261	SKCM	ICGC	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.3056
p.P321H	DO37420	SKCM	ICGC	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2222
p.L600V	DO43306	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1944
p.V327G	SIDM02039	Colorectal Carcinoma	GDSC	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation altering degron motif	0.7532
p.V320G	SIDM00568	Gastric Carcinoma	GDSC	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.1944
p.V320G	ACH-000247	Gastric Cancer	CCLE	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.1944
p.V320G	OCUM-1	stomach	COSMIC	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.1944
p.G585S	SIDM00301	Pancreatic Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1667
p.G585S	SIDM01608	Endometrial Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1667
p.G585S	KP-4	pancreas	COSMIC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1667
p.P583H	SIDM00694	Other Solid Cancers	GDSC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1111
p.G592R	SIDM00489	Oral Cavity Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation altering degron motif	0.6457
p.G592R	ACH-002043	Head and Neck Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation altering degron motif	0.6457
p.G592R	Ca9-22	upper aerodigestive tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation altering degron motif	0.6457
p.A584T	SIDM00217	Colorectal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1389
p.A584T	ACH-000999	Colon/Colorectal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1389
p.A584T	SNU-1040	large intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation rewiring degron network	0.1389
p.Y323H	SIDM01619	Endometrial Carcinoma	GDSC	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2778
p.Y323H	ACH-000984	Endometrial/Uterine Cancer	CCLE	LSVFLE	LIG_APCC_ABBA_1	325:330	Mutation rewiring degron network	0.2778
p.V286G	OCUM-1	stomach	COSMIC	DFTSELVPSY	DEG_COP1_1	267:276	Mutation rewiring degron network	0.0556
p.R594W	FU97	stomach	COSMIC	VGSSS	DEG_SPOP_SBC_1	591:595	Mutation altering degron motif	0.8634

Kaplan plot for TRIM37 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM37

UniProt ID: O94972

Entrez ID: 4591

Protein name: E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM37 in