DegronMD

Uniprot ID: O94972

Source protein: E3 ubiquitin-protein ligase TRIM37

Source gene: TRIM37

Class: LIG_APCC_ABBA_1

Location: 325:330

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5198

ASA_SCORE: 11.65

COIL: 0.0507

CONS_SCORE: 0.6883

DSS_SCORE: 0.0374

HELIX: 0.0127

FCONS_SCORE: 1.3851

RIG_SCORE: 0.964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V327L	TCGA-DD-A3A8	LIHC	TCGA	LSVFLE	LIG_APCC_ABBA_1	0.5654
p.S332L	TCGA-E5-A4TZ	BLCA	TCGA	LSVFLE	LIG_APCC_ABBA_1	0.2778
p.K323E	DO233647	GACA	ICGC	LSVFLE	LIG_APCC_ABBA_1	0.2778
p.N324K	DO47261	SKCM	ICGC	LSVFLE	LIG_APCC_ABBA_1	0.3056
p.P321H	DO37420	SKCM	ICGC	LSVFLE	LIG_APCC_ABBA_1	0.2222
p.V327G	SIDM02039	Colorectal Carcinoma	GDSC	LSVFLE	LIG_APCC_ABBA_1	0.7532
p.V320G	SIDM00568	Gastric Carcinoma	GDSC	LSVFLE	LIG_APCC_ABBA_1	0.1944
p.V320G	ACH-000247	Gastric Cancer	CCLE	LSVFLE	LIG_APCC_ABBA_1	0.1944
p.V320G	OCUM-1	stomach	COSMIC	LSVFLE	LIG_APCC_ABBA_1	0.1944
p.Y323H	SIDM01619	Endometrial Carcinoma	GDSC	LSVFLE	LIG_APCC_ABBA_1	0.2778
p.Y323H	ACH-000984	Endometrial/Uterine Cancer	CCLE	LSVFLE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94972	E3 ubiquitin-protein ligase TRIM37	LIG_APCC_ABBA_1	325:330	LSVFLE	APC,CDC20,FZR1	0.5198	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons