DegronMD

Uniprot ID: O94972

Source protein: E3 ubiquitin-protein ligase TRIM37

Source gene: TRIM37

Class: DEG_COP1_1

Location: 267:276

E3 ligase: COP1

DEGRON score: 0.9386

ASA_SCORE: 62.49

COIL: 0.7187

CONS_SCORE: 0.6159

DSS_SCORE: 0.2861

HELIX: 0.1412

FCONS_SCORE: 1.2649

RIG_SCORE: 0.774

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T262A	TCGA-BS-A0UV	UCEC	TCGA	DFTSELVPSY	DEG_COP1_1	0.6389
p.P263S	TCGA-C4-A0F1	BLCA	TCGA	DFTSELVPSY	DEG_COP1_1	0.2222
p.E284D	TCGA-CA-6717	COAD	TCGA	DFTSELVPSY	DEG_COP1_1	0.1111
p.D267N	TCGA-CA-6717	COAD	TCGA	DFTSELVPSY	DEG_COP1_1	0.6932
p.F286L	TCGA-FS-A1ZP	SKCM	TCGA	DFTSELVPSY	DEG_COP1_1	0.0556
p.P274S	TCGA-MX-A5UJ	STAD	TCGA	DFTSELVPSY	DEG_COP1_1	0.6752
p.G271V	DO51915	BLCA	ICGC	DFTSELVPSY	DEG_COP1_1	0.7532
p.G271V	DO223723	LUSC	ICGC	DFTSELVPSY	DEG_COP1_1	0.7532
p.Q268E	DO2919	BRCA	ICGC	DFTSELVPSY	DEG_COP1_1	0.6744
p.P261T	DO6290	CESC	ICGC	DFTSELVPSY	DEG_COP1_1	0.6111
p.V286G	OCUM-1	stomach	COSMIC	DFTSELVPSY	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94972	E3 ubiquitin-protein ligase TRIM37	DEG_COP1_1	267:276	DFTSELVPSY	COP1	0.9386	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons