DegronMD - Q5VST9(OBSCN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A3642V	TCGA-06-5416	GBM	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation blocking phosphorylation signal	0.6944
p.A3642V	TCGA-AA-A010	COAD	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation blocking phosphorylation signal	0.6944
p.A3642V	TCGA-AF-2693	READ	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation blocking phosphorylation signal	0.6944
p.A3642V	DO48282	ESCA	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation blocking phosphorylation signal	0.6944
p.A3642V	DO10880	GBM	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation blocking phosphorylation signal	0.6944
p.A3642V	DO36766	READ	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation blocking phosphorylation signal	0.6944
p.A3890V	TCGA-18-3409	LUSC	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.2778
p.A3890V	DO26444	LUSC	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.2778
p.R1038K	TCGA-2F-A9KT	BLCA	TCGA	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1389
p.R1038K	DO52599	BOCA	ICGC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1389
p.V2767A	TCGA-2W-A8YY	CESC	TCGA	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.0556
p.V2767A	DO223732	CESC	ICGC	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.0556
p.R4850L	TCGA-37-4135	LUSC	TCGA	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.R4850L	DO26806	LUSC	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.A2593S	TCGA-49-AAR2	LUAD	TCGA	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.2778
p.A2593S	DO218918	LUAD	ICGC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.2778
p.A3906T	TCGA-55-A48X	LUAD	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.1667
p.A3906T	DO24048	LUAD	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.1667
p.I7952M	TCGA-67-3771	LUAD	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.1111
p.E5420D	TCGA-91-6831	LUAD	TCGA	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation altering degron motif	0.6758
p.A3906S	TCGA-91-6836	LUAD	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.1667
p.A3906S	DO23854	LUAD	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.1667
p.T6176K	TCGA-97-A4M7	LUAD	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.1111
p.T6176K	DO45386	LUAD	ICGC	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.1111
p.M6151L	TCGA-98-A53B	LUSC	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.0833
p.R4995H	TCGA-A5-A0G2	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.8244
p.R4995H	DO41235	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.8244
p.R4995H	ACH-001956	Bone Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.8244
p.C1035R	TCGA-A5-A0GP	UCEC	TCGA	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.2222
p.T5409I	TCGA-A6-3809	COAD	TCGA	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.0833
p.L4853Q	TCGA-A6-6653	COAD	TCGA	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.2778
p.L4853Q	DO10373	COAD	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.2778
p.G7956R	TCGA-AA-3492	COAD	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.2222
p.G7956R	TCGA-EE-A2GC	SKCM	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.2222
p.R3662C	TCGA-AA-3815	COAD	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.R3662C	TCGA-B5-A11J	UCEC	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.R3662C	TCGA-M8-A5N4	PAAD	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.R3662C	DO9924	COAD	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.R3662C	DO50264	PAAD	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.R3662C	DO43698	UCEC	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.A4294T	TCGA-AA-3864	COAD	TCGA	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.1944
p.A4294T	DO8490	COAD	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.1944
p.A5415V	TCGA-AC-A8OP	BRCA	TCGA	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.25
p.A5415V	SIDM00217	Colorectal Carcinoma	GDSC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.25
p.A5415V	ACH-000999	Colon/Colorectal Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.25
p.A5415V	SNU-1040	large intestine	COSMIC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.25
p.R1038S	TCGA-AG-3891	READ	TCGA	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1389
p.S4292F	TCGA-AG-3892	READ	TCGA	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.25
p.S4292F	DO36394	READ	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.25
p.R2773C	TCGA-AP-A051	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.2222
p.R2773C	DO42673	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.2222
p.T1036M	TCGA-AX-A063	UCEC	TCGA	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1944
p.T1036M	SIDM02035	Colorectal Carcinoma	GDSC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1944
p.A728V	TCGA-AX-A2HJ	UCEC	TCGA	AREVLARLH	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1389
p.A728V	DO42105	UCEC	ICGC	AREVLARLH	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1389
p.A2605T	TCGA-B5-A11E	UCEC	TCGA	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.1944
p.A2605T	DO41644	UCEC	ICGC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.1944
p.R4274I	TCGA-B5-A11E	UCEC	TCGA	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.1389
p.R4274I	DO41644	UCEC	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.1389
p.R1037H	TCGA-B5-A3FC	UCEC	TCGA	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1667
p.A2589T	TCGA-B5-A3FC	UCEC	TCGA	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.1667
p.A2589T	DO41871	UCEC	ICGC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.1667
p.M6151I	TCGA-BQ-7045	KIRP	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.0833
p.V3652I	TCGA-D1-A17Q	UCEC	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation altering degron motif	0.7076
p.V3652I	DO41903	UCEC	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation altering degron motif	0.7076
p.V3652I	SIDM02015	Colorectal Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation altering degron motif	0.7076
p.E2785K	TCGA-D3-A51J	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.2222
p.E2785K	DO47359	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.2222
p.R4850Q	TCGA-D3-A51N	SKCM	TCGA	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.R4850Q	DO47274	SKCM	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.T7967A	TCGA-D3-A8GP	SKCM	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation altering degron motif	0.7139
p.G2770D	TCGA-D5-6927	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.1389
p.G2770D	DO10332	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.1389
p.P7958T	TCGA-D9-A1X3	SKCM	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.2778
p.P7958T	SIDM01617	Endometrial Carcinoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.2778
p.P7958T	ACH-000994	Endometrial/Uterine Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.2778
p.Q4279L	TCGA-DD-AACQ	LIHC	TCGA	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.2778
p.Q4279L	DO52211	LIHC	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.2778
p.P3655L	TCGA-EB-A24D	SKCM	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.2778
p.P3655L	DO37440	SKCM	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.2778
p.P3196Q	TCGA-EE-A29E	SKCM	TCGA	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.1111
p.P3196Q	DO37831	SKCM	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.1111
p.R6155S	TCGA-EE-A29Q	SKCM	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.1944
p.G3893E	TCGA-EE-A29S	SKCM	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation altering degron motif	0.7199
p.G3893E	DO37936	SKCM	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation altering degron motif	0.7199
p.E3892K	TCGA-EE-A3AG	SKCM	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation altering degron motif	0.7022
p.E3892K	DO37471	SKCM	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation altering degron motif	0.7022
p.V5416G	TCGA-EO-A22X	UCEC	TCGA	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.2778
p.R6172S	TCGA-ER-A19N	SKCM	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.2222
p.P7971Q	TCGA-ER-A19P	SKCM	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.25
p.H7957Y	TCGA-FI-A2D0	UCEC	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.25
p.H7957Y	DO43891	UCEC	ICGC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.25
p.D5001V	TCGA-FI-A2D5	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.2778
p.D5001V	DO41331	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.2778
p.E6983K	TCGA-FI-A2D5	UCEC	TCGA	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation rewiring degron network	0.1111
p.E6983K	TCGA-PE-A5DE	BRCA	TCGA	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation rewiring degron network	0.1111
p.E6983K	DO219643	BRCA	ICGC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation rewiring degron network	0.1111
p.E6983K	DO41331	UCEC	ICGC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation rewiring degron network	0.1111
p.G2965S	TCGA-FW-A3R5	SKCM	TCGA	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.0833
p.G2965S	DO37406	SKCM	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.0833
p.D3195N	TCGA-FW-A3R5	SKCM	TCGA	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.0833
p.D3195N	DO37406	SKCM	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.0833
p.A4858V	TCGA-G4-6297	COAD	TCGA	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.6936
p.A4858V	DO9418	COAD	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.6936
p.A4858V	DO228618	GACA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.6936
p.A4858V	SIDM02041	Colorectal Carcinoma	GDSC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.6936
p.A4858V	SIDM00217	Colorectal Carcinoma	GDSC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.6936
p.A4858V	ACH-000999	Colon/Colorectal Cancer	CCLE	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.6936
p.A4858V	SNU-1040	large intestine	COSMIC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.6936
p.R4995C	TCGA-G5-6235	READ	TCGA	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.8301
p.R4995C	TCGA-HU-A4GQ	STAD	TCGA	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.8301
p.R4995C	DO35184	PACA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.8301
p.R4995C	DO36612	READ	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.8301
p.R4995C	DO47767	STAD	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.8301
p.P3196S	TCGA-GN-A8LK	SKCM	TCGA	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.1111
p.P3196S	DO51259	SKCM	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.1111
p.P3196L	TCGA-GN-A8LK	SKCM	TCGA	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.1111
p.P3196L	DO51259	SKCM	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.1111
p.E4872K	TCGA-HQ-A5NE	BLCA	TCGA	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.0833
p.E4872K	DO51900	BLCA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.0833
p.R6155C	TCGA-HT-A74K	LGG	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.1944
p.Q4867K	TCGA-HU-8238	STAD	TCGA	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.2222
p.Q4867K	DO47944	STAD	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.2222
p.R6172H	TCGA-IG-A3I8	ESCA	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.2222
p.R6172H	ACH-002687	Metastasis	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.2222
p.G4996A	TCGA-K4-A54R	BLCA	TCGA	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.754
p.G4996A	DO48611	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.754
p.G7968R	TCGA-KU-A66S	HNSC	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation altering degron motif	0.7568
p.G7968R	DO44456	HNSC	ICGC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation altering degron motif	0.7568
p.E6159K	TCGA-N7-A4Y5	UCS	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.3056
p.Q3213H	TCGA-OR-A5KB	ACC	TCGA	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.3056
p.T4865P	TCGA-VP-AA1N	PRAD	TCGA	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.2778
p.T4865P	DO51393	PRAD	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.2778
p.E729K	TCGA-VS-A94Z	CESC	TCGA	AREVLARLH	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1111
p.E729K	DO51634	CESC	ICGC	AREVLARLH	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1111
p.W3910C	TCGA-WA-A7H4	HNSC	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.0556
p.W3910C	DO219097	HNSC	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.0556
p.P3907A	TCGA-XF-A8HF	BLCA	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.1389
p.P3907A	DO49800	BLCA	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.1389
p.C1029Y	TCGA-XK-AAIW	PRAD	TCGA	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.7087
p.R3211C	DO225226	BRCA	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation altering degron motif	0.8301
p.R3211C	DO233888	GACA	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation altering degron motif	0.8301
p.S215F	DO224768	BRCA	ICGC	PGTST	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.9093
p.S4871L	DO4810	BRCA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation blocking phosphorylation signal	0.5556
p.S4998F	DO51646	CESC	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7982
p.S4998F	DO37782	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7982
p.L5422M	DO10598	COAD	ICGC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation altering degron motif	0.711
p.R4856H	DO8842	COAD	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.8244
p.R5008C	DO8642	COAD	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.0833
p.R5008C	DO234231	ESAD	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.0833
p.A1032V	DO8264	COAD	ICGC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.3056
p.T5434A	DO230326	COCA	ICGC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.0556
p.R2958Q	DO230334	COCA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.2778
p.R2958Q	DO229016	COCA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.2778
p.R2958Q	DO229003	COCA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.2778
p.R2958Q	DO234285	ESAD	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.2778
p.R2958Q	DO231056	LUSC	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.2778
p.R5008H	DO230346	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.0833
p.G4996R	DO227999	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7568
p.G4996R	DO229013	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7568
p.G4996R	DO229005	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7568
p.G4996R	DO229505	LAML	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7568
p.G4996R	DO230659	LAML	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7568
p.G4996R	DO230931	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7568
p.G4996R	DO230993	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7568
p.G4996R	DO230990	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7568
p.H2048R	DO229010	COCA	ICGC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.0556
p.H2048R	DO229013	COCA	ICGC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.0556
p.H2048R	DO229016	COCA	ICGC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.0556
p.H2048R	DO229003	COCA	ICGC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.0556
p.H2048R	DO229005	COCA	ICGC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.0556
p.H2048R	DO229047	LICA	ICGC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.0556
p.H2048R	DO230937	LUSC	ICGC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.0556
p.A218V	DO234285	ESAD	ICGC	PGTST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.2778
p.A218V	DO234284	ESAD	ICGC	PGTST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.2778
p.D4273E	DO228612	GACA	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.1111
p.S3208T	DO225448	GACA	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation altering degron motif	0.7116
p.A728T	DO233219	GACA	ICGC	AREVLARLH	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1389
p.R5009W	DO233652	GACA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.0556
p.R2955H	DO233854	GACA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation altering degron motif	0.8244
p.S4854L	DO233869	GACA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.3056
p.D6972A	DO12952	GBM	ICGC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation altering degron motif	0.7793
p.L4291R	DO15703	HNSC	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.2778
p.E4276K	DO52087	HNSC	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.1944
p.E4276K	DO36556	READ	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.1944
p.A4997G	DO49761	KIRP	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.754
p.V3644L	DO228916	LICA	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.3056
p.K2944N	DO228941	LICA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.2222
p.C3900F	DO228952	LICA	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation altering degron motif	0.7108
p.R5008L	DO228952	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.0833
p.S2778I	DO229018	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation altering degron motif	0.7341
p.A1032S	DO229029	LICA	ICGC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.3056
p.A5006S	DO229025	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.1389
p.G4297W	DO229025	LICA	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.1111
p.M5409I	DO229027	LICA	ICGC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.0833
p.A3197S	DO229027	LICA	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.1389
p.E4850D	DO229027	LICA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.G6985V	DO229026	LICA	ICGC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation rewiring degron network	0.0556
p.E5000D	DO229031	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.3056
p.S2938F	DO229036	LICA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation substituting flanking lysine	0.1667
p.S4863I	DO229038	LICA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.623
p.G5001V	DO229037	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.2778
p.V6967L	DO229045	LICA	ICGC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation rewiring degron network	0.2778
p.M2030I	DO229056	LICA	ICGC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.25
p.V1030L	DO229008	LICA	ICGC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.5654
p.A2587S	DO229008	LICA	ICGC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.1111
p.M5431V	DO24245	LUAD	ICGC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.1389
p.G5000V	DO23874	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.3056
p.M4872I	DO45314	LUAD	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.0833
p.M4872K	DO45314	LUAD	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.0833
p.M4872V	DO23976	LUAD	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.0833
p.V1041L	DO24920	LUAD	ICGC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.0556
p.E3888K	DO220872	MELA	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.2222
p.P4845S	DO220882	MELA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.0556
p.D2784V	DO222532	MELA	ICGC	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.25
p.P2939S	DO222753	MELA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.0833
p.E4856D	DO232832	NACA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.6758
p.Q4859R	DO233297	NACA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.7329
p.A4854S	DO27921	ORCA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.3056
p.Q4848H	DO31510	OV	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1389
p.L1022P	DO28731	OV	ICGC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.2222
p.S4989I	DO34136	PACA	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.1667
p.G3202S	DO232761	PBCA	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.2778
p.G3202S	ACH-001377	Pancreatic Cancer	CCLE	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.2778
p.A2593T	DO232224	PBCA	ICGC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.2778
p.E729A	DO232445	PBCA	ICGC	AREVLARLH	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1111
p.E729A	ACH-001329	Brain Cancer	CCLE	AREVLARLH	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1111
p.A2605V	DO50105	PEME	ICGC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.1944
p.T2598P	DO36556	READ	ICGC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation altering degron motif	0.7031
p.P4870S	DO229453	SKCA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1389
p.P4870S	DO41235	UCEC	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1389
p.D4279N	DO38288	STAD	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.2778
p.Q4847R	DO229268	THCA	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1111
p.Q5408H	DO229216	THCA	ICGC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.0556
p.S410G	DO229216	THCA	ICGC	ICETPEGS	DEG_SCF_FBW7_1	403:410	Mutation altering degron motif	0.6993
p.R1036G	DO229234	THCA	ICGC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1944
p.G4868C	DO42336	UCEC	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.R4856C	DO43186	UCEC	ICGC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.8301
p.R3216C	DO43763	UCEC	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation substituting flanking lysine	0.3333
p.R3216C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation substituting flanking lysine	0.3333
p.R3216C	ACH-000937	Leukemia	CCLE	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation substituting flanking lysine	0.3333
p.R3216C	PF-382	haematopoietic and lymphoid tissue	COSMIC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation substituting flanking lysine	0.3333
p.S4999Y	DO42665	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.712
p.R2601W	SIDM02026	Colorectal Carcinoma	GDSC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.3056
p.D2963G	SIDM01278	Colorectal Carcinoma	GDSC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.1389
p.S6165F	SIDM00791	Chronic Myelogenous Leukemia	GDSC	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation altering degron motif	0.7982
p.S6165F	ACH-000551	Leukemia	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation altering degron motif	0.7982
p.S6165F	ACH-002061	Leukemia	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation altering degron motif	0.7982
p.S6165F	K-562	haematopoietic and lymphoid tissue	COSMIC	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation altering degron motif	0.7982
p.A3890S	SIDM00216	Colorectal Carcinoma	GDSC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.2778
p.A3890S	ACH-000989	Colon/Colorectal Cancer	CCLE	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.2778
p.A3890S	SNU-175	large intestine	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.2778
p.V3644M	SIDM00373	Endometrial Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.3056
p.V3644M	ACH-000974	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.3056
p.V3644M	ACH-002026	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.3056
p.V3644M	SNG-M	endometrium	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.3056
p.A1032P	SIDM00422	Hodgkin's Lymphoma	GDSC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.3056
p.A1032P	ACH-001203	Lymphoma	CCLE	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.3056
p.A1032P	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.3056
p.Y2600H	SIDM01104	Melanoma	GDSC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation altering degron motif	0.7229
p.Y2600H	ACH-000640	Skin Cancer	CCLE	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation altering degron motif	0.7229
p.Y2600H	SK-MEL-31	skin	COSMIC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation altering degron motif	0.7229
p.V5430M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.1667
p.V5430M	ACH-000995	Leukemia	CCLE	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.1667
p.V5430M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.1667
p.Y2035F	SIDM00845	Burkitt's Lymphoma	GDSC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation altering degron motif	0.7528
p.Y2035F	SIDM00461	Acute Myeloid Leukemia	GDSC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation altering degron motif	0.7528
p.Y2035F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation altering degron motif	0.7528
p.Y2035F	SIDM01519	Head and Neck Carcinoma	GDSC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation altering degron motif	0.7528
p.A7950G	SIDM01090	Colorectal Carcinoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.0556
p.R4283I	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation altering degron motif	0.8102
p.R4283I	ACH-000697	Lymphoma	CCLE	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation altering degron motif	0.8102
p.R4283I	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation altering degron motif	0.8102
p.G4272E	SIDM00107	Melanoma	GDSC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.0833
p.G4272E	ACH-000425	Skin Cancer	CCLE	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.0833
p.G4272E	ACH-002004	Skin Cancer	CCLE	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.0833
p.G4272E	UACC-62	skin	COSMIC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.0833
p.E7977K	SIDM01174	Cervical Carcinoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.0833
p.E7977K	ACH-001402	Cervical Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.0833
p.E7977K	SW756	cervix	COSMIC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.0833
p.P6971L	SIDM01175	Other Sarcomas	GDSC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation altering degron motif	0.7582
p.P6971L	SW684	soft tissue	COSMIC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation altering degron motif	0.7582
p.R1038M	SIDM00789	Colorectal Carcinoma	GDSC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1389
p.R1038M	ACH-001061	Colon/Colorectal Cancer	CCLE	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1389
p.R1038M	HCT-15	large intestine	COSMIC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1389
p.A7974V	SIDM00846	Cervical Carcinoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.1667
p.A7974V	HeLa	cervix	COSMIC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.1667
p.V2032M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.3056
p.V2032M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.3056
p.A2587V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.1111
p.A2587V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation rewiring degron network	0.1111
p.C1029F	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.7108
p.C1029F	ACH-000647	Esophageal Cancer	CCLE	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.7108
p.C1029F	TE-1	oesophagus	COSMIC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.7108
p.M1030V	SIDM00231	Kidney Carcinoma	GDSC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.7208
p.M1030V	ACH-002167	Kidney Cancer	CCLE	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.7208
p.M1030V	NCC010	kidney	COSMIC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.7208
p.S2596N	SIDM01178	Other Solid Cancers	GDSC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation altering degron motif	0.7069
p.S2596N	SIDM00274	Gastric Carcinoma	GDSC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation altering degron motif	0.7069
p.S2596N	ACH-000047	Gastric Cancer	CCLE	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation altering degron motif	0.7069
p.S2596N	SW962	vulva	COSMIC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation altering degron motif	0.7069
p.S2596N	GCIY	stomach	COSMIC	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation altering degron motif	0.7069
p.E722K	SIDM00854	Burkitt's Lymphoma	GDSC	AREVLARLH	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.3056
p.C2790Y	SIDM01079	Melanoma	GDSC	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.0833
p.C2790Y	SH-4	skin	COSMIC	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.0833
p.G4272R	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.0833
p.G4272R	ACH-002254	Lymphoma	CCLE	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.0833
p.G4272R	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.0833
p.Q4854H	SIDM00963	Breast Carcinoma	GDSC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.3056
p.Q4854H	BT-474	breast	COSMIC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.3056
p.R4850W	SIDM00585	Hepatocellular Carcinoma	GDSC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.R4850W	SIDM00217	Colorectal Carcinoma	GDSC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.R4850W	SIDM01619	Endometrial Carcinoma	GDSC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.R4850W	SNU-1040	large intestine	COSMIC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.R4850W	HuH-7	liver	COSMIC	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.1944
p.S3660I	SIDM01088	Endometrial Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.1389
p.S3660I	ACH-000965	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.1389
p.S3660I	RL95-2	endometrium	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.1389
p.R3662P	SIDM00837	Colorectal Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.R3662P	ACH-000958	Colon/Colorectal Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.R3662P	SW48	large intestine	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.R225L	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PGTST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0833
p.A5428T	SIDM00214	Colorectal Carcinoma	GDSC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.2222
p.E6974Q	SIDM00006	Other Solid Cancers	GDSC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation altering degron motif	0.6744
p.E6974Q	ACH-001552	Skin Cancer	CCLE	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation altering degron motif	0.6744
p.E6974Q	MCC26	skin	COSMIC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation altering degron motif	0.6744
p.H222Y	SIDM00537	Colorectal Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1667
p.H222Y	ACH-001345	Colon/Colorectal Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1667
p.R2955P	SIDM01000	Melanoma	GDSC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation altering degron motif	0.7512
p.R2955P	WM-115	skin	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation altering degron motif	0.7512
p.A217V	SIDM00176	Chondrosarcoma	GDSC	PGTST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.3056
p.Q4287L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation altering degron motif	0.7765
p.Q4287L	ACH-000878	Lung Cancer	CCLE	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation altering degron motif	0.7765
p.Q4287L	HCC-15	lung	COSMIC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation altering degron motif	0.7765
p.G5003V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.2222
p.G5003V	KYSE-150	oesophagus	COSMIC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation rewiring degron network	0.2222
p.S3210N	SIDM00150	Colorectal Carcinoma	GDSC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation altering degron motif	0.5958
p.S3210N	ACH-000969	Colon/Colorectal Cancer	CCLE	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation altering degron motif	0.5958
p.S3210N	KM12	large intestine	COSMIC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation altering degron motif	0.5958
p.P7958S	SIDM01228	Melanoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.2778
p.P7958S	ACH-001024	Skin Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.2778
p.P7958S	CHL-1	skin	COSMIC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.2778
p.G7968A	SIDM01503	Small Cell Lung Carcinoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation altering degron motif	0.754
p.G7968A	ACH-000844	Lung Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation altering degron motif	0.754
p.W2034R	SIDM01608	Endometrial Carcinoma	GDSC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation altering degron motif	0.8634
p.R3662H	SIDM01617	Endometrial Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.R3662H	ACH-000994	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.0833
p.K6168N	SIDM01570	Ovarian Carcinoma	GDSC	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation altering degron motif	0.6918
p.K6168N	ACH-000324	Ovarian Cancer	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation altering degron motif	0.6918
p.E5420K	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation altering degron motif	0.7022
p.E5420K	ACH-000553	Lung Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation altering degron motif	0.7022
p.G6163S	SIDM00500	Colorectal Carcinoma	GDSC	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation altering degron motif	0.5882
p.G6163S	ACH-000959	Colon/Colorectal Cancer	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation altering degron motif	0.5882
p.E1031G	SIDM01424	B-Lymphoblastic Leukemia	GDSC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.7199
p.E1031G	ACH-000782	Leukemia	CCLE	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.7199
p.E1031G	ACH-001735	Leukemia	CCLE	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation altering degron motif	0.7199
p.D4866H	ACH-000071	Non-Cancerous	CCLE	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation rewiring degron network	0.25
p.G6151V	ACH-000369	Leukemia	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.0833
p.G6151V	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.0833
p.R2595K	ACH-000851	Lung Cancer	CCLE	MPLYND	LIG_APCC_ABBA_1	2595:2600	Mutation altering degron motif	0.7237
p.V401M	ACH-000911	Gastric Cancer	CCLE	ICETPEGS	DEG_SCF_FBW7_1	403:410	Mutation rewiring degron network	0.2778
p.G2039C	ACH-000920	Leukemia	CCLE	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.3056
p.Q3897H	ACH-000927	Breast Cancer	CCLE	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation altering degron motif	0.647
p.Q3897H	BT-474	breast	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation altering degron motif	0.647
p.S7966T	ACH-000961	Endometrial/Uterine Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation altering degron motif	0.7116
p.Y402C	ACH-000962	Ovarian Cancer	CCLE	ICETPEGS	DEG_SCF_FBW7_1	403:410	Mutation rewiring degron network	0.3056
p.Y402C	ACH-001145	Ovarian Cancer	CCLE	ICETPEGS	DEG_SCF_FBW7_1	403:410	Mutation rewiring degron network	0.3056
p.D6176G	ACH-000964	Leukemia	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	6160:6168	Mutation rewiring degron network	0.1111
p.A5429T	ACH-000974	Endometrial/Uterine Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.1944
p.V2045A	ACH-000990	Endometrial/Uterine Cancer	CCLE	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.1389
p.P5421S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation altering degron motif	0.6752
p.G5422S	ACH-000996	Endometrial/Uterine Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation altering degron motif	0.5882
p.A3642G	ACH-001024	Skin Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation blocking phosphorylation signal	0.6944
p.A711T	ACH-001031	Rhabdoid	CCLE	AREVLARLH	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.2778
p.T6971P	ACH-001113	Lung Cancer	CCLE	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation altering degron motif	0.8142
p.F2783L	ACH-001306	Thyroid Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.2778
p.S4862Y	ACH-001369	Ovarian Cancer	CCLE	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.712
p.D202N	ACH-001567	Skin Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0556
p.G5427S	ACH-001609	Brain Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	5418:5424	Mutation rewiring degron network	0.25
p.A218T	ACH-001610	Brain Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.2778
p.S3208G	ACH-001610	Brain Cancer	CCLE	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation altering degron motif	0.6993
p.Q7975P	ACH-001645	Skin Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	7960:7968	Mutation rewiring degron network	0.1389
p.E4860D	ACH-001796	Liposarcoma	CCLE	VRPPLGDLS	DEG_APCC_DBOX_1	4855:4863	Mutation altering degron motif	0.6758
p.P3643A	ACH-001853	Bile Duct Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.2778
p.R2787C	PF-382	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation rewiring degron network	0.1667
p.H6960Y	C-4-I	cervix	COSMIC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation rewiring degron network	0.0833
p.A3653G	IGROV-1	ovary	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation altering degron motif	0.6429
p.D4297G	LIM1215	large intestine	COSMIC	ARWALGGVP	DEG_APCC_DBOX_1	4281:4289	Mutation rewiring degron network	0.1111
p.R3893W	SNU-1040	large intestine	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation altering degron motif	0.8634
p.R3893W	HuH-7	liver	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation altering degron motif	0.8634
p.A3901V	SNU-1040	large intestine	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.3056
p.V3885I	NCI-H2110	lung	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	3892:3900	Mutation rewiring degron network	0.1389
p.G2951D	JHH-4	liver	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation altering degron motif	0.6087
p.C6979R	NCI-H1651	lung	COSMIC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation rewiring degron network	0.2222
p.A4995T	HCT-15	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.7139
p.E2038K	SW756	cervix	COSMIC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation altering degron motif	0.7022
p.A2943T	KYSE-150	oesophagus	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.1944
p.Q2965K	A498	kidney	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.0833
p.R6962C	Sarc9371	bone	COSMIC	PSTPRPS	DEG_SCF_FBW7_1	6969:6975	Mutation rewiring degron network	0.1389
p.H2941Q	ECC12	stomach	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation rewiring degron network	0.1389
p.V3655L	NCI-H441	lung	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation rewiring degron network	0.2778
p.R2956Q	MEG-01	haematopoietic and lymphoid tissue	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	2948:2956	Mutation altering degron motif	0.6218
p.V3215M	SNG-M	endometrium	COSMIC	LRCVLSSVA	DEG_APCC_DBOX_1	3204:3212	Mutation rewiring degron network	0.25
p.R1037Q	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1667
p.D1018G	Caov-4	ovary	COSMIC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1111
p.R2041P	647-V	urinary tract	COSMIC	VEIHAE	LIG_APCC_ABBA_1	2033:2038	Mutation rewiring degron network	0.25
p.R3646W	HUH-6-clone5	liver	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	3645:3653	Mutation altering degron motif	0.8634
p.S2781N	KM12	large intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	2777:2781	Mutation altering degron motif	0.7069
p.R1037C	RL95-2	endometrium	COSMIC	LKVHVE	LIG_APCC_ABBA_1	1026:1031	Mutation rewiring degron network	0.1667
p.E4996K	DBTRG-05MG	central nervous system	COSMIC	AESSS	DEG_SPOP_SBC_1	4995:4999	Mutation altering degron motif	0.591

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OBSCN

UniProt ID: Q5VST9

Entrez ID: 84033

Protein name: Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OBSCN in