DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_APCC_DBOX_1

Location: 4281:4289

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6625

ASA_SCORE: 50.2222

COIL: 0.228

CONS_SCORE: 0.4202

DSS_SCORE: 0.3461

HELIX: 0.0039

FCONS_SCORE: 1.0416

RIG_SCORE: 0.7533

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A4294T	TCGA-AA-3864	COAD	TCGA	ARWALGGVP	DEG_APCC_DBOX_1	0.1944
p.A4294T	DO8490	COAD	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	0.1944
p.S4292F	TCGA-AG-3892	READ	TCGA	ARWALGGVP	DEG_APCC_DBOX_1	0.25
p.S4292F	DO36394	READ	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	0.25
p.R4274I	TCGA-B5-A11E	UCEC	TCGA	ARWALGGVP	DEG_APCC_DBOX_1	0.1389
p.R4274I	DO41644	UCEC	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	0.1389
p.Q4279L	TCGA-DD-AACQ	LIHC	TCGA	ARWALGGVP	DEG_APCC_DBOX_1	0.2778
p.Q4279L	DO52211	LIHC	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	0.2778
p.D4273E	DO228612	GACA	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	0.1111
p.L4291R	DO15703	HNSC	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	0.2778
p.E4276K	DO52087	HNSC	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	0.1944
p.E4276K	DO36556	READ	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	0.1944
p.G4297W	DO229025	LICA	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	0.1111
p.D4279N	DO38288	STAD	ICGC	ARWALGGVP	DEG_APCC_DBOX_1	0.2778
p.R4283I	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARWALGGVP	DEG_APCC_DBOX_1	0.8102
p.R4283I	ACH-000697	Lymphoma	CCLE	ARWALGGVP	DEG_APCC_DBOX_1	0.8102
p.R4283I	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	ARWALGGVP	DEG_APCC_DBOX_1	0.8102
p.G4272E	SIDM00107	Melanoma	GDSC	ARWALGGVP	DEG_APCC_DBOX_1	0.0833
p.G4272E	ACH-000425	Skin Cancer	CCLE	ARWALGGVP	DEG_APCC_DBOX_1	0.0833
p.G4272E	ACH-002004	Skin Cancer	CCLE	ARWALGGVP	DEG_APCC_DBOX_1	0.0833
p.G4272E	UACC-62	skin	COSMIC	ARWALGGVP	DEG_APCC_DBOX_1	0.0833
p.G4272R	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARWALGGVP	DEG_APCC_DBOX_1	0.0833
p.G4272R	ACH-002254	Lymphoma	CCLE	ARWALGGVP	DEG_APCC_DBOX_1	0.0833
p.G4272R	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	ARWALGGVP	DEG_APCC_DBOX_1	0.0833
p.Q4287L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ARWALGGVP	DEG_APCC_DBOX_1	0.7765
p.Q4287L	ACH-000878	Lung Cancer	CCLE	ARWALGGVP	DEG_APCC_DBOX_1	0.7765
p.Q4287L	HCC-15	lung	COSMIC	ARWALGGVP	DEG_APCC_DBOX_1	0.7765
p.D4297G	LIM1215	large_intestine	COSMIC	ARWALGGVP	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARWALGGVP

Degron related mutations and impact score

Drug responses associated with OBSCN mutations

All proteins holding degron of ARWALGGVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_APCC_DBOX_1	4281:4289	ARWALGGVP	APC,CDC20,FZR1	0.6625	More...