DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_APCC_DBOX_1

Location: 3892:3900

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7634

ASA_SCORE: 85.7556

COIL: 0.5394

CONS_SCORE: 0.5159

DSS_SCORE: 0.5117

HELIX: 0.0117

FCONS_SCORE: 0.9391

RIG_SCORE: 0.7665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3890V	TCGA-18-3409	LUSC	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	0.2778
p.A3890V	DO26444	LUSC	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	0.2778
p.A3906T	TCGA-55-A48X	LUAD	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	0.1667
p.A3906T	DO24048	LUAD	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	0.1667
p.A3906S	TCGA-91-6836	LUAD	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	0.1667
p.A3906S	DO23854	LUAD	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	0.1667
p.G3893E	TCGA-EE-A29S	SKCM	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	0.7199
p.G3893E	DO37936	SKCM	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	0.7199
p.E3892K	TCGA-EE-A3AG	SKCM	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	0.7022
p.E3892K	DO37471	SKCM	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	0.7022
p.W3910C	TCGA-WA-A7H4	HNSC	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	0.0556
p.W3910C	DO219097	HNSC	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	0.0556
p.P3907A	TCGA-XF-A8HF	BLCA	TCGA	FREPLQSLQ	DEG_APCC_DBOX_1	0.1389
p.P3907A	DO49800	BLCA	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	0.1389
p.C3900F	DO228952	LICA	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	0.7108
p.E3888K	DO220872	MELA	ICGC	FREPLQSLQ	DEG_APCC_DBOX_1	0.2222
p.A3890S	SIDM00216	Colorectal Carcinoma	GDSC	FREPLQSLQ	DEG_APCC_DBOX_1	0.2778
p.A3890S	ACH-000989	Colon/Colorectal Cancer	CCLE	FREPLQSLQ	DEG_APCC_DBOX_1	0.2778
p.A3890S	SNU-175	large_intestine	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	0.2778
p.Q3897H	ACH-000927	Breast Cancer	CCLE	FREPLQSLQ	DEG_APCC_DBOX_1	0.647
p.Q3897H	BT-474	breast	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	0.647
p.R3893W	SNU-1040	large_intestine	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	0.8634
p.R3893W	HuH-7	liver	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	0.8634
p.A3901V	SNU-1040	large_intestine	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	0.3056
p.V3885I	NCI-H2110	lung	COSMIC	FREPLQSLQ	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_APCC_DBOX_1	3892:3900	FREPLQSLQ	APC,CDC20,FZR1	0.7634	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FREPLQSLQ

Degron related mutations and impact score

Drug responses associated with OBSCN mutations

All proteins holding degron of FREPLQSLQ