DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_SCF_FBW7_1

Location: 6969:6975

E3 ligase: FBXW7

DEGRON score: 0.981

ASA_SCORE: 86.7143

COIL: 0.9349

CONS_SCORE: 0.2534

DSS_SCORE: 0.7733

HELIX: 0.0391

FCONS_SCORE: 1.045

RIG_SCORE: 0.5101

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T6971P	ACH-001113	Lung Cancer	CCLE	PSTPRPS	DEG_SCF_FBW7_1	0.8142
p.D6972A	DO12952	GBM	ICGC	PSTPRPS	DEG_SCF_FBW7_1	0.7793
p.P6971L	SIDM01175	Other Sarcomas	GDSC	PSTPRPS	DEG_SCF_FBW7_1	0.7582
p.P6971L	SW684	soft_tissue	COSMIC	PSTPRPS	DEG_SCF_FBW7_1	0.7582
p.E6974Q	SIDM00006	Other Solid Cancers	GDSC	PSTPRPS	DEG_SCF_FBW7_1	0.6744
p.E6974Q	ACH-001552	Skin Cancer	CCLE	PSTPRPS	DEG_SCF_FBW7_1	0.6744
p.E6974Q	MCC26	skin	COSMIC	PSTPRPS	DEG_SCF_FBW7_1	0.6744
p.V6967L	DO229045	LICA	ICGC	PSTPRPS	DEG_SCF_FBW7_1	0.2778
p.C6979R	NCI-H1651	lung	COSMIC	PSTPRPS	DEG_SCF_FBW7_1	0.2222
p.R6962C	Sarc9371	bone	COSMIC	PSTPRPS	DEG_SCF_FBW7_1	0.1389
p.E6983K	TCGA-FI-A2D5	UCEC	TCGA	PSTPRPS	DEG_SCF_FBW7_1	0.1111
p.E6983K	TCGA-PE-A5DE	BRCA	TCGA	PSTPRPS	DEG_SCF_FBW7_1	0.1111
p.E6983K	DO219643	BRCA	ICGC	PSTPRPS	DEG_SCF_FBW7_1	0.1111
p.E6983K	DO41331	UCEC	ICGC	PSTPRPS	DEG_SCF_FBW7_1	0.1111
p.H6960Y	C-4-I	cervix	COSMIC	PSTPRPS	DEG_SCF_FBW7_1	0.0833
p.G6985V	DO229026	LICA	ICGC	PSTPRPS	DEG_SCF_FBW7_1	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_SCF_FBW7_1	6969:6975	PSTPRPS	FBXW7	0.981	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons