DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_SCF_FBW7_1

Location: 5418:5424

E3 ligase: FBXW7

DEGRON score: 0.9658

ASA_SCORE: 57.5143

COIL: 0.711

CONS_SCORE: 0.5618

DSS_SCORE: 0.3269

HELIX: 0.0166

FCONS_SCORE: 1.0147

RIG_SCORE: 0.7488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E5420D	TCGA-91-6831	LUAD	TCGA	PDTPGYT	DEG_SCF_FBW7_1	0.6758
p.T5409I	TCGA-A6-3809	COAD	TCGA	PDTPGYT	DEG_SCF_FBW7_1	0.0833
p.A5415V	TCGA-AC-A8OP	BRCA	TCGA	PDTPGYT	DEG_SCF_FBW7_1	0.25
p.A5415V	SIDM00217	Colorectal Carcinoma	GDSC	PDTPGYT	DEG_SCF_FBW7_1	0.25
p.A5415V	ACH-000999	Colon/Colorectal Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	0.25
p.A5415V	SNU-1040	large_intestine	COSMIC	PDTPGYT	DEG_SCF_FBW7_1	0.25
p.V5416G	TCGA-EO-A22X	UCEC	TCGA	PDTPGYT	DEG_SCF_FBW7_1	0.2778
p.L5422M	DO10598	COAD	ICGC	PDTPGYT	DEG_SCF_FBW7_1	0.711
p.T5434A	DO230326	COCA	ICGC	PDTPGYT	DEG_SCF_FBW7_1	0.0556
p.M5409I	DO229027	LICA	ICGC	PDTPGYT	DEG_SCF_FBW7_1	0.0833
p.M5431V	DO24245	LUAD	ICGC	PDTPGYT	DEG_SCF_FBW7_1	0.1389
p.Q5408H	DO229216	THCA	ICGC	PDTPGYT	DEG_SCF_FBW7_1	0.0556
p.V5430M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PDTPGYT	DEG_SCF_FBW7_1	0.1667
p.V5430M	ACH-000995	Leukemia	CCLE	PDTPGYT	DEG_SCF_FBW7_1	0.1667
p.V5430M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PDTPGYT	DEG_SCF_FBW7_1	0.1667
p.A5428T	SIDM00214	Colorectal Carcinoma	GDSC	PDTPGYT	DEG_SCF_FBW7_1	0.2222
p.E5420K	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PDTPGYT	DEG_SCF_FBW7_1	0.7022
p.E5420K	ACH-000553	Lung Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	0.7022
p.A5429T	ACH-000974	Endometrial/Uterine Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	0.1944
p.P5421S	ACH-000990	Endometrial/Uterine Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	0.6752
p.G5422S	ACH-000996	Endometrial/Uterine Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	0.5882
p.G5427S	ACH-001609	Brain Cancer	CCLE	PDTPGYT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_SCF_FBW7_1	5418:5424	PDTPGYT	FBXW7	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons