DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_SCF_FBW7_1

Location: 403:410

E3 ligase: FBXW7

DEGRON score: 0.7363

ASA_SCORE: 56.525

COIL: 0.5403

CONS_SCORE: 0.5626

DSS_SCORE: 0.318

HELIX: 0.0114

FCONS_SCORE: 0.8948

RIG_SCORE: 0.7853

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S410G	DO229216	THCA	ICGC	ICETPEGS	DEG_SCF_FBW7_1	0.6993
p.V401M	ACH-000911	Gastric Cancer	CCLE	ICETPEGS	DEG_SCF_FBW7_1	0.2778
p.Y402C	ACH-000962	Ovarian Cancer	CCLE	ICETPEGS	DEG_SCF_FBW7_1	0.3056
p.Y402C	ACH-001145	Ovarian Cancer	CCLE	ICETPEGS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_SCF_FBW7_1	403:410	ICETPEGS	FBXW7	0.7363	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons