DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_APCC_DBOX_1

Location: 6160:6168

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7

ASA_SCORE: 48.3

COIL: 0.416

CONS_SCORE: 0.6047

DSS_SCORE: 0.1165

HELIX: 0.0213

FCONS_SCORE: 1.2299

RIG_SCORE: 0.8643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T6176K	TCGA-97-A4M7	LUAD	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	0.1111
p.T6176K	DO45386	LUAD	ICGC	PRSGLLVLV	DEG_APCC_DBOX_1	0.1111
p.M6151L	TCGA-98-A53B	LUSC	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	0.0833
p.M6151I	TCGA-BQ-7045	KIRP	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	0.0833
p.R6155S	TCGA-EE-A29Q	SKCM	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	0.1944
p.R6172S	TCGA-ER-A19N	SKCM	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	0.2222
p.R6155C	TCGA-HT-A74K	LGG	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	0.1944
p.R6172H	TCGA-IG-A3I8	ESCA	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	0.2222
p.R6172H	ACH-002687	Metastasis	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	0.2222
p.E6159K	TCGA-N7-A4Y5	UCS	TCGA	PRSGLLVLV	DEG_APCC_DBOX_1	0.3056
p.S6165F	SIDM00791	Chronic Myelogenous Leukemia	GDSC	PRSGLLVLV	DEG_APCC_DBOX_1	0.7982
p.S6165F	ACH-000551	Leukemia	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	0.7982
p.S6165F	ACH-002061	Leukemia	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	0.7982
p.S6165F	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	PRSGLLVLV	DEG_APCC_DBOX_1	0.7982
p.K6168N	SIDM01570	Ovarian Carcinoma	GDSC	PRSGLLVLV	DEG_APCC_DBOX_1	0.6918
p.K6168N	ACH-000324	Ovarian Cancer	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	0.6918
p.G6163S	SIDM00500	Colorectal Carcinoma	GDSC	PRSGLLVLV	DEG_APCC_DBOX_1	0.5882
p.G6163S	ACH-000959	Colon/Colorectal Cancer	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	0.5882
p.G6151V	ACH-000369	Leukemia	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	0.0833
p.G6151V	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	PRSGLLVLV	DEG_APCC_DBOX_1	0.0833
p.D6176G	ACH-000964	Leukemia	CCLE	PRSGLLVLV	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_APCC_DBOX_1	6160:6168	PRSGLLVLV	APC,CDC20,FZR1	0.7	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons