DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_APCC_DBOX_1

Location: 2948:2956

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7185

ASA_SCORE: 83.7333

COIL: 0.435

CONS_SCORE: 0.547

DSS_SCORE: 0.3894

HELIX: 0.0019

FCONS_SCORE: 1.0238

RIG_SCORE: 0.8388

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2965S	TCGA-FW-A3R5	SKCM	TCGA	WRKGLLELR	DEG_APCC_DBOX_1	0.0833
p.G2965S	DO37406	SKCM	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	0.0833
p.R2958Q	DO230334	COCA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	0.2778
p.R2958Q	DO229016	COCA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	0.2778
p.R2958Q	DO229003	COCA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	0.2778
p.R2958Q	DO234285	ESAD	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	0.2778
p.R2958Q	DO231056	LUSC	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	0.2778
p.R2955H	DO233854	GACA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	0.8244
p.K2944N	DO228941	LICA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	0.2222
p.S2938F	DO229036	LICA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	0.1667
p.P2939S	DO222753	MELA	ICGC	WRKGLLELR	DEG_APCC_DBOX_1	0.0833
p.D2963G	SIDM01278	Colorectal Carcinoma	GDSC	WRKGLLELR	DEG_APCC_DBOX_1	0.1389
p.R2955P	SIDM01000	Melanoma	GDSC	WRKGLLELR	DEG_APCC_DBOX_1	0.7512
p.R2955P	WM-115	skin	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	0.7512
p.G2951D	JHH-4	liver	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	0.6087
p.A2943T	KYSE-150	oesophagus	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	0.1944
p.Q2965K	A498	kidney	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	0.0833
p.H2941Q	ECC12	stomach	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	0.1389
p.R2956Q	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	WRKGLLELR	DEG_APCC_DBOX_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_APCC_DBOX_1	2948:2956	WRKGLLELR	APC,CDC20,FZR1	0.7185	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons