DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: LIG_APCC_ABBA_1

Location: 2595:2600

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5366

ASA_SCORE: 77.5

COIL: 0.2558

CONS_SCORE: 0.5861

DSS_SCORE: 0.2671

HELIX: 0.0048

FCONS_SCORE: 1.0819

RIG_SCORE: 0.734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2593S	TCGA-49-AAR2	LUAD	TCGA	MPLYND	LIG_APCC_ABBA_1	0.2778
p.A2593S	DO218918	LUAD	ICGC	MPLYND	LIG_APCC_ABBA_1	0.2778
p.A2605T	TCGA-B5-A11E	UCEC	TCGA	MPLYND	LIG_APCC_ABBA_1	0.1944
p.A2605T	DO41644	UCEC	ICGC	MPLYND	LIG_APCC_ABBA_1	0.1944
p.A2589T	TCGA-B5-A3FC	UCEC	TCGA	MPLYND	LIG_APCC_ABBA_1	0.1667
p.A2589T	DO41871	UCEC	ICGC	MPLYND	LIG_APCC_ABBA_1	0.1667
p.A2587S	DO229008	LICA	ICGC	MPLYND	LIG_APCC_ABBA_1	0.1111
p.A2593T	DO232224	PBCA	ICGC	MPLYND	LIG_APCC_ABBA_1	0.2778
p.A2605V	DO50105	PEME	ICGC	MPLYND	LIG_APCC_ABBA_1	0.1944
p.T2598P	DO36556	READ	ICGC	MPLYND	LIG_APCC_ABBA_1	0.7031
p.R2601W	SIDM02026	Colorectal Carcinoma	GDSC	MPLYND	LIG_APCC_ABBA_1	0.3056
p.Y2600H	SIDM01104	Melanoma	GDSC	MPLYND	LIG_APCC_ABBA_1	0.7229
p.Y2600H	ACH-000640	Skin Cancer	CCLE	MPLYND	LIG_APCC_ABBA_1	0.7229
p.Y2600H	SK-MEL-31	skin	COSMIC	MPLYND	LIG_APCC_ABBA_1	0.7229
p.A2587V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	MPLYND	LIG_APCC_ABBA_1	0.1111
p.A2587V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	MPLYND	LIG_APCC_ABBA_1	0.1111
p.S2596N	SIDM01178	Other Solid Cancers	GDSC	MPLYND	LIG_APCC_ABBA_1	0.7069
p.S2596N	SIDM00274	Gastric Carcinoma	GDSC	MPLYND	LIG_APCC_ABBA_1	0.7069
p.S2596N	ACH-000047	Gastric Cancer	CCLE	MPLYND	LIG_APCC_ABBA_1	0.7069
p.S2596N	SW962	vulva	COSMIC	MPLYND	LIG_APCC_ABBA_1	0.7069
p.S2596N	GCIY	stomach	COSMIC	MPLYND	LIG_APCC_ABBA_1	0.7069
p.R2595K	ACH-000851	Lung Cancer	CCLE	MPLYND	LIG_APCC_ABBA_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	LIG_APCC_ABBA_1	2595:2600	MPLYND	APC,CDC20,FZR1	0.5366	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons